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Pregled bibliografske jedinice broj: 901264

Molecular imaging of alkaloids in khat (Catha edulis) leaves with MeV-SIMS

Jenčič, Boštjan; Jeromel, Luka; Ogrinc Potočnik, Nina; Vogel-Mikuš, Katarina; Vavpetič, Primož; Rupnik, Zdravko; Bučar, Klemen; Vencelj, Matjaž; Kelemen, Mitja; Matsuo, Jiro et al.
Molecular imaging of alkaloids in khat (Catha edulis) leaves with MeV-SIMS // Nuclear instruments & methods in physics research. Section B : Beam interactions with materials and atoms, 404 (2017), 140-145 doi:10.1016/j.nimb.2017.01.063 (međunarodna recenzija, članak, znanstveni)

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Naslov
Molecular imaging of alkaloids in khat (Catha edulis) leaves with MeV-SIMS

Autori
Jenčič, Boštjan ; Jeromel, Luka ; Ogrinc Potočnik, Nina ; Vogel-Mikuš, Katarina ; Vavpetič, Primož ; Rupnik, Zdravko ; Bučar, Klemen ; Vencelj, Matjaž ; Kelemen, Mitja ; Matsuo, Jiro ; Kusakari, Masakazu ; Siketić, Zdravko ; Al-Jalali, Muhammad Ahmad ; Shaltout, Abdallah A. ; Pelicon, Primož

Izvornik
Nuclear instruments & methods in physics research. Section B : Beam interactions with materials and atoms (0168-583X) 404 (2017); 140-145

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Imaging Mass Spectroscopy ; Khat ; MeV-SIMS ; Nuclear microprobe

Sažetak
Imaging Mass Spectroscopy (IMS) is a unique research tool providing localization and identification of a wide range of biomolecules as essential data to understand biochemical processes in living organisms. Secondary Ion Mass Spectrometry with high-energy heavy ions (MeV-SIMS) is emerging as a promising IMS technique for chemical imaging of biological tissue. We measured the molecular mass spatial distributions in leaves of khat (Catha edulis). Khat is a natural drug plant, native to eastern Africa and the Arabian Peninsula. In these countries, fresh leaves are being chewed by significant part of population. It was reported that 80% of the adult population in Yemen chew the khat leaves. The main stimulating effects of khat are induced by a monoamine alkaloid called cathinone. During leaf ageing, cathinone is further metabolised to cathine and norephedrine. Earlier studies identified the alkaloids in khat, however little is known on their spatial distribution, reflecting the biosynthesis and accumulation in the tissue. Chemical mapping of alkaloids on cross-sections of khat leaves by MeV-SIMS was done at JSI by a pulsed 5.8 MeV 35Cl6+ beam, focused to a diameter of 15 μm, using a linear time-of-flight (TOF) spectrometer with a mass resolution of 500. In addition, measurements of MeV-SIMS mass spectra were performed at Kyoto University by a continuous broad beam of 6 MeV 63Cu4+ ions at an orthogonal TOF spectrometer with a high mass resolution of 11, 000. Sections of leaves were analysed and mass spectra obtained at both MeV-SIMS setups were compared. Tissue-level distributions of detected alkaloids are presented and discussed.

Izvorni jezik
Engleski

Znanstvena područja
Fizika



POVEZANOST RADA

Ustanove:
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Zdravko Siketić (autor)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com doi.org

Citiraj ovu publikaciju:

Jenčič, Boštjan; Jeromel, Luka; Ogrinc Potočnik, Nina; Vogel-Mikuš, Katarina; Vavpetič, Primož; Rupnik, Zdravko; Bučar, Klemen; Vencelj, Matjaž; Kelemen, Mitja; Matsuo, Jiro et al.
Molecular imaging of alkaloids in khat (Catha edulis) leaves with MeV-SIMS // Nuclear instruments & methods in physics research. Section B : Beam interactions with materials and atoms, 404 (2017), 140-145 doi:10.1016/j.nimb.2017.01.063 (međunarodna recenzija, članak, znanstveni)
Jenčič, B., Jeromel, L., Ogrinc Potočnik, N., Vogel-Mikuš, K., Vavpetič, P., Rupnik, Z., Bučar, K., Vencelj, M., Kelemen, M. & Matsuo, J. (2017) Molecular imaging of alkaloids in khat (Catha edulis) leaves with MeV-SIMS. Nuclear instruments & methods in physics research. Section B : Beam interactions with materials and atoms, 404, 140-145 doi:10.1016/j.nimb.2017.01.063.
@article{article, author = {Jen\v{c}i\v{c}, Bo\v{s}tjan and Jeromel, Luka and Ogrinc Poto\v{c}nik, Nina and Vogel-Miku\v{s}, Katarina and Vavpeti\v{c}, Primo\v{z} and Rupnik, Zdravko and Bu\v{c}ar, Klemen and Vencelj, Matja\v{z} and Kelemen, Mitja and Matsuo, Jiro and Kusakari, Masakazu and Siketi\'{c}, Zdravko and Al-Jalali, Muhammad Ahmad and Shaltout, Abdallah A. and Pelicon, Primo\v{z}}, year = {2017}, pages = {140-145}, DOI = {10.1016/j.nimb.2017.01.063}, keywords = {Imaging Mass Spectroscopy, Khat, MeV-SIMS, Nuclear microprobe}, journal = {Nuclear instruments and methods in physics research. Section B : Beam interactions with materials and atoms}, doi = {10.1016/j.nimb.2017.01.063}, volume = {404}, issn = {0168-583X}, title = {Molecular imaging of alkaloids in khat (Catha edulis) leaves with MeV-SIMS}, keyword = {Imaging Mass Spectroscopy, Khat, MeV-SIMS, Nuclear microprobe} }
@article{article, author = {Jen\v{c}i\v{c}, Bo\v{s}tjan and Jeromel, Luka and Ogrinc Poto\v{c}nik, Nina and Vogel-Miku\v{s}, Katarina and Vavpeti\v{c}, Primo\v{z} and Rupnik, Zdravko and Bu\v{c}ar, Klemen and Vencelj, Matja\v{z} and Kelemen, Mitja and Matsuo, Jiro and Kusakari, Masakazu and Siketi\'{c}, Zdravko and Al-Jalali, Muhammad Ahmad and Shaltout, Abdallah A. and Pelicon, Primo\v{z}}, year = {2017}, pages = {140-145}, DOI = {10.1016/j.nimb.2017.01.063}, keywords = {Imaging Mass Spectroscopy, Khat, MeV-SIMS, Nuclear microprobe}, journal = {Nuclear instruments and methods in physics research. Section B : Beam interactions with materials and atoms}, doi = {10.1016/j.nimb.2017.01.063}, volume = {404}, issn = {0168-583X}, title = {Molecular imaging of alkaloids in khat (Catha edulis) leaves with MeV-SIMS}, keyword = {Imaging Mass Spectroscopy, Khat, MeV-SIMS, Nuclear microprobe} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus

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