Naslov
Kleptomania - a side - effect induced by venlafaxine

Autori
Jukić, Vlado ; Makarić, Porin ; Ćurković, Marko ; Radić, Krešimir ; Brečić, Petrana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Skup
30th CINP (The International College of Neuropsychopharmacology), World Congress of Neuropsychopharmacology

Mjesto i datum
Seoul, Republika Koreja, 03.06.2016. - 05.06.2016

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
SNRI, kleptomania, MDD

Sažetak
Venlafaxine is a dual serotonin and norepinephrine reuptake inhibitor (SNRI), widely used as a treatment of the major depressive disorder (MDD), social anxiety disorder, and generalized anxiety disorder. Venalfaxine is generally considered quite effective and safe, with commonly reported adverse reactions in clinical studies being nausea, dry mouth, headache and sweating. Kleptomania is a rare impulse control disorder characterized by recurrent episodes of compulsive stealing, most commonly in the form of shoplifting. The stolen items are usually of trivial value, and not needed by the person stealing them. Kleptomanic behaviour during treatment with antidepressants was reported in several occasions, but was usually induced by serotonin selective reuptake inhibitors. Methods We present a clinical case of a female patient treated with venlafaxine for MDD that developed kleptomania. Results Our patient was admitted to a psychiatric unit, presenting depressive symptoms that met ICD-10 criteria for a recurrent, severe MDD without psychotic features. Patient was primary treated with venlafaxine that in subsequent weeks expressed as clinically significant and subjective satisfactory control of leading symptoms. After discharge, patient continued psychiatric outpatient treatment. Eight months after her first hospital treatment, patient was readmitted: her depressive symptoms were recurring after she started to shoplift regularly and compulsively. As venlafaxine was discontinued and a new antidepressant, bupropion, was given, patients compulsion vanished, leading to conclusion that kleptomania could have been induced by venlafaxine treatment. In subsequent follow up of the patient, there were no signs of kleptomania. That was followed by good and stable remission of symptoms reoccurring within primary disorder. Conclusion So far, kleptomania as side effect of venlafaxine treatment has been reported from several different sources. Possible pathophysiological causes are further discussed leading to the conclusion that norepinephrinergic pathways, above and beyond, serotoninergic ones, can contribute to the occurrence of this rare and unique side effect.

Izvorni jezik
Engleski

POVEZANOST RADA