Naslov
Clostridium difficile infection in the Surgical intensive Care Unite: a case series.
(Nesek Adam V, Markić A, Mršić V, Grizelj Stojčić E, Goranović T, Matolić M, Tonković D. Clostridium difficile infection in the Surgical intensive Care Unite: a case series.)

Autori
Nesek Adam, Višnja ; Markić, A. ; Mršić, Viviana ; Grizelj Stojčić, Elvira ; Goranović, Tatjana ; Matolić, Martina ; Tonković, Dinko

Izvornik
Neurologia Croatica. Supplement (1331-5196) 61 (2012), 2; 59-64

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, stručni

Ključne riječi
Clostridium difficile, infekcija, kirurgija
(Clostridium difficile, infection, surgery)

Sažetak
Background: Clostridium difficile infection is a frequent cause of morbidity and mortality among hospitalized patients. The clinical presentation of C difficile infection ranges from mild antibiotic-associated diarrhea to more severe pseudomembranous colitis and toxic megacolon. A small number of patients developed fulminant C difficile infection, and some of these patients require emergency operation and admission to the intensive care unit. Methods: We retrospectively analyzed the clinical course and outcome of 14 patients with C difficile infection with clinically distinct forms over the 12-months period admitted to our Surgical Intensive Care Unit and offered a brief review of current and emerging therapeutic options in this setting. Results: All patients received antibiotics for other illnesses. Patients with severe C difficile colitis were more likely to have abdominal pain, tenderness, distention, peritonitis, and elevated or suppressed white blood cell count. Three patients who presented with acute abdomen underwent emergency surgery. One underwent subtotal colectomy and the other, a hemicolectomy with ileostomy. In one patients only an exploratory laparotomy was performed. Eleven were treated conservatively. The mortality rate was 28 %. All patients who presented with an acute abdomen and one patient without surgical intervention died. Conclusion: Patients with severe C difficile colitis presenting as an acute abdomen still represents a lethal entity.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA