Naslov
Pharmacogenomic Testing in the Era of Patient- Tailored HCV Treatment

Autori
Smolić, Martina ; Omanović, Tea ; Božić, Ivana ; Bilić-Čurčić, Ines ; Smolić, Robert ; Včev, Aleksandar

Vrsta, podvrsta i kategorija rada
Poglavlja u knjigama, stručni

Knjiga
Update on Hepatitis C

Urednik/ci
Smolić, Martina ; Včev, Aleksandar ; Y. Wu, George

Izdavač
IntechOpen

Grad
Rijeka

Godina
2017

Raspon stranica
173-189

ISBN
978-953-51-3564-7

Ključne riječi
hepatitis C virus, pharmacogenetics, pegylated interferon and ribavirin, direct-acting antiviral agents, genetic polymorphisms, IL-28B, ITP A

Sažetak
Hepatitis C affects approximately 180 million people worldwide, with 3–4 million newly infected each year. Hepatitis C virus (HCV) has been classified into seven different genotype categories, wherein HCV genotype 1 (HCV-1) is the most prevalent. To date, there is still no vaccine available against HCV infection. Until recently, combination therapy of pegylated interferon-a (PegIFN) and ribavirin (RBV) has been the standard of care. Nevertheless, for many patients, particularly those infected with HCV genotype 1 (HCV-1), this treatment has resulted with unsatisfactory treatment response rates and high adverse drug reaction (ADR) rates. Many clinical factors, including pharmacogenetics, influence the treatment response rate. This review focuses on the association between pharmacogenetics and HCV antiviral therapy in patients infected with HCV genotype 1 and other genotypes (GT) ; patients reinfected with HCV after liver transplantation ; and patients coinfected with HCV and human immunodeficiency virus. Data considering triple therapy in HCV-infected patients are also reviewed. Additionally, various genetic polymorphisms, with an empha - sis to IL-28B, and their association with pharmacogenetic testing in HCV are discussed

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA