Naslov
Protective intraoperative ventilation with higher versus lower levels of positive end- expiratory pressure in obese patients (PROBESE): study protocol for a randomized controlled trial.

Autori
Bluth, Thomas ; ... ; Klarić, Vlasta ; Vitković, Bibiana ; Milić, Morena ; Zupčić, Miro ; ... ; Schultz, M. ; Pelosi, Paolo ; Gama de Abrem, M.

Kolaboracija
PROBESE investigators ; PROtective VEntilation Network (PROVEnet) ; Clinical Trial Network of the European Society of Anaesthesiology (ESA)

Izvornik
Trials (1745-6215) 18 (2017); 202, 22

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Mechanical ventilation ; Obesity ; Positive end-expiratory pressure ; Postoperative pulmonary complication ; Recruitment maneuver

Sažetak
Postoperative pulmonary complications (PPCs) increase the morbidity and mortality of surgery in obese patients. High levels of positive end- expiratory pressure (PEEP) with lung recruitment maneuvers may improve intraoperative respiratory function, but they can also compromise hemodynamics, and the effects on PPCs are uncertain. We hypothesized that intraoperative mechanical ventilation using high PEEP with periodic recruitment maneuvers, as compared with low PEEP without recruitment maneuvers, prevents PPCs in obese patients. To our knowledge, the PROBESE trial is the first multicenter, international randomized controlled trial to compare the effects of two different levels of intraoperative PEEP during protective low tidal volume ventilation on PPCs in obese patients. The results of the PROBESE trial will support anesthesiologists in their decision to choose a certain PEEP level during general anesthesia for surgery in obese patients in an attempt to prevent PPCs.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA