Naslov
Development of tools for modulation of genes involved in protein glycosylation by genome editing.

Autori
Bočkor, Luka ; Tadić, Vanja ; Dobrinić, Paula ; Markulin, Dora ; Vojta, Aleksandar ; Zoldoš, Vlatka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
2nd International Meeting Genome editing & gene modulation congress 2016 / - , 2016

Skup
2nd International Meeting GENOME EDITING & GENE MODULATION CONGRESS 2016. 2nd International Meeting GENOME EDITING & GENE MODULATION CONGRESS 2016.

Mjesto i datum
Oxford, Ujedinjeno Kraljevstvo, 06.04.2016. - 08.04.2016

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
IgG glycosylation, genome editing, HNF1A, BACH2

Sažetak
Glycosylation is one of the most important post-translational modifications of proteins contributing to a number of functions in protein biology, from protein folding and quality control to recognition events such as cell signalling and immune surveillance. Glycans have come into focus recently as contributors or cause of different human complex diseases. A recent GWAS study of the IgG glycosylation identified several genes with the IL6ST locus being among the top hits. IgG represents an excellent model glycoprotein because it has one glycosylation site at each heavy chain. Many of the structures present on IgG have been well defined with many important functional effects of alternative IgG glycosylation described...

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Biotehnologija

POVEZANOST RADA