Naslov
HLA-B/HLA-C Region Is Associated with Familial Juvenile Onset Psoriasis in Croatian Patients
(HLA-B/HLA-C Region is associated with Familial Juvenile Onset Psoriasis in Croatian Patients)

Autori
Pašić, Aida ; Grahovac, Blaženka ; Dražić, Vesna ; Lipozenčić, Jasna ; Basta-Juzbašić, Aleksandra ; Čeović, Romana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the 2nd Joint Meeting International Psoriasis Symposium and European Congress on Psoriasis / SDEF - San Francisco (CA) : Skin disease education foundation, 2001, 144-144

Skup
2nd Joint Meeting International Psoriasis Symposium and European Congress on Psoriasis (2 ; 2001)

Mjesto i datum
San Francisco (CA), Sjedinjene Američke Države, 19.06.2001. - 24.06.2001

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
HLA regions; psoriasis; Croatia

Sažetak
To evaluate the nature of the HLA association with psoriasis, HLA-haplotypes of 58 unrelated patients with type I psoriasis (early onset, <40 years, positive family history) were investigated by high-resolution PCR-based typing with sequence specific primers for HLA class I and II. Volunteer blood donors were typed as a controls (N=78). Results showed 34, 5% of patients to be positive for HLA-B/-C region of extended haplotype EH-57.1(Cw*0602-B*57) previously described as the most frequent psoriasis associated haplotype, and 27, 6% of patients demonstrated Cw*0602-B*13 haplotype, both highly overrepresented (p<0.001) compared to only 2.1% and 1.8% in control, respectively. Further analysis of individual HLA alleles revealed that HLA class I antigens were to a great extent associate with type I psoriasis: Cw*0602 with a gene frequency of 0.345 in patients vs. 0.0658 in control (p<0.001, RR=14.6), B*57 0.172 vs. 0.0116 (p<0.001, RR=19.4) and B*13 0.138 vs. 0.011 (p<0.001, RR=14.1). Pedigree analysis of the four affected families over two to three generations, revealed cosegregation of the disease with HLA-B/-C region. In our patient group, there was evidence of a prental sex effect ; 53.7% of patients had an affected father, while 24.3% patients had an affected mother (p=0.06).

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

Napomena
Rad je kao predavanje prezentiran i na skupu 2nd Congress of Croatian Dermatovenerologists with International participation, održanom od 16.-19.05. 2002., Opatija, Hrvatska ; sažeci objavljeni u Acta Dermatovenerologica Croatica 10 (2002)(2).

POVEZANOST RADA