Naslov
Assesment of perforin expression in peripheral blood lymphocytes in psoriatic patients during exacerbation of disease

Autori
Prpić, Larisa ; Štrbo, Nataša ; Sotošek, Vlatka ; Gruber, Franjo, Podack, Eckhard R. ; Rukavina, Daniel

Izvornik
Acta dermato-venereologica (0001-5555) 211 (2000); 14-16

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Psoriasis ; Perforin ; Cytotoxic T lymphocytes ; NK cells

Sažetak
There are very few data concerning the role played by cell-mediated cytotoxicity, particularly at the molecular level, in the course of psoriasis. Both cytotoxic T lymphocytes (CTL) and antural killer cells contain in their granules the cytolytic protein perforin, a mediator in cell-mediated cytotoxicity reactions. The aim of this study was to analyze perforin expression in various sets and subsets of perforin-positive peripheral blood lymphocytes in 17 patients with chronic psoriasis vulgaris in the exacerbation phase. The results were compared with those of an age- and sex- matched healthy control group (n=21). Perforin (intracellular antigen) and cell surface antigens were detected using the simultaneous double- staining method. We found a significant increase in perforin (P) expression in the patient group for CTL (CD3+P+ cells), which are located mostly in the CD8+ population of T lymphocytes (CD8+P+).

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Farmacija

POVEZANOST RADA