Naslov
Drug induced photosensitivity - a continuous diagnostic challenge

Autori
Lugović-Mihić, Liborija ; Duvančić, Tomislav ; Ferček, Iva ; Vuković, Petra ; Japundžić, Iva ; Ćesić, Diana

Izvornik
Acta clinica Croatica (0353-9466) 56 (2017), 2; 277-283

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, ostalo

Ključne riječi
drug, photosensitivity, phototoxic, photoallergic, skin, dermatitis

Sažetak
When taking different drugs, there are possible side-effects on the skin, among which are also skin reactions connected to photosensitivity of the drug. This photosensitivity caused by drugs can appear as phototoxic reactions (which are more often), or photoallergic reactions (which are less often and include allergic mechanisms). As medications with high photosensitivity potential, these drugs stand out: amiodarone, NSAIDs, phenothiazines (especially chlorpromazine), retinoids, thiazides, and others as well as several groups of antibiotics (sulfonamides, tetracyclines, especially demeclocycline and quinolones). Phototoxic and photoallergic reactions appear in the form of different inflammatory changes on parts of skin which are exposed to sunlight, especially the face, neck, fists and forearms. More extended skin changes are usually a sign of exposure to a systemic photosensitising agent, while localized changes point to a reaction to locally applied topical photosensitisers. So patients who, in their process of recovery, use potentially photosensitive drugs and treatments on a long term basis, should be warned of the possibility of these side-effects on their skin, and should be advised to avoid direct exposure to sunlight, as well as to use adequate photoprotection. If the measures of sun protection are taken timely, it is often not necessary to stop treatments that include photosensitive drugs. In case such reactions do show up, anti-inflammatory and antiallergic therapy should be induced.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Farmacija

POVEZANOST RADA