Naslov
On cluster sizes during lens growth in the mouse

Autori
Šikić, Hrvoje ; Bassnett, Steven

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
ARVO Annual Meeting Abstract ; u: Investigative ophthalmology & visual science 57 (2016) (12) / - , 2016, 3064-3064

Skup
ARVO Annual Meeting

Mjesto i datum
Seattle (WA), Sjedinjene Američke Države, 09.2016

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Eye lens ; growth model ; Clusters

Sažetak
Use of a stochastic lens growth model allows the size of epithelial cell clusters to be calculated as a function of both time and latitudinal position on the lens surface. The distribution of predicted cluster sizes was consistent with results of lineage tracing studies. The pause in CZ growth from three to six months has the effect of skewing the cluster size distribution towards smaller values. We hypothesize that this effect would serve to minimize the likelihood of deleterious somatic mutations flowing from sun-exposed regions of the epithelium into the fiber cell body.

Izvorni jezik
Engleski

Znanstvena područja
Matematika, Biologija, Temeljne medicinske znanosti

POVEZANOST RADA