Naslov
Impact of linker between triazolyl-uracil and phenanthridine on recognition of DNA and RNA. Recognition of uracil – containing RNA.

Autori
Saftić, Dijana ; Radić Stojković, Marijana ; Žinić, Biserka ; Glavaš-Obrovac, Ljubica ; Jukić, Marijana ; Piantanida, Ivo ; Tumir, Lidija-Marija

Izvornik
New journal of chemistry (1144-0546) 41 (2017), 22; 13240-13252

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
phenanthridine, triazole, uracil, conjugate, DNA, RNA, binding, selectivity, spectroscopy, fluorescence

Sažetak
A new group of multifunctional ligands for DNA and RNA were prepared, comprising phenanthridinium and triazolyluracil connected by various aliphatic or peptide linkers. The peptide linker conjugates showed at least order of magnitude higher affinity in comparison to aliphatic analogues, which was attributed to peptide-specific hydrophobic and hydrogen bonding interactions within DNA/RNA binding sites. Particularly, peptide-linker conjugate with lysine residue showed selectivity toward poly rA-poly rU, as well as toward poly U, both characterized by strong affinity and selective fluorescence response. Negligible cytotoxicity of compounds additionally supported their possible applications as fluorimetric probes in laboratory use.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA