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Pregled bibliografske jedinice broj: 892923

Prognostic value of vitamin D level for all-cause mortality, and association with inflammatory markers, in HIV-infected persons

Shepherd, L.; Souberbielle, J.C.; Bastard, J.P.; Fellahi, S.; Capeau, J.; Reekie, J.; Reiss, P.; Blaxhult, A.; Bickel, M.; Leen, C. et al.
Prognostic value of vitamin D level for all-cause mortality, and association with inflammatory markers, in HIV-infected persons // The Journal of infectious diseases, 210 (2014), 2; 234-243 doi:10.1093/infdis/jiu074 (međunarodna recenzija, članak, znanstveni)

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Naslov
Prognostic value of vitamin D level for all-cause mortality, and association with inflammatory markers, in HIV-infected persons

Autori
Shepherd, L. ; Souberbielle, J.C. ; Bastard, J.P. ; Fellahi, S. ; Capeau, J. ; Reekie, J. ; Reiss, P. ; Blaxhult, A. ; Bickel, M. ; Leen, C. ; Kirk, O. ; Lundgren, J.D. ; Mocroft, A. ; Viard, J.P. ; ... ; Begovac, Josip ; ...

Izvornik
The Journal of infectious diseases (0022-1899) 210 (2014), 2; 234-243

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
C-reactive protein ; HIV ; IL-6 ; all-cause death ; inflammation ; soluble CD14 ; vitamin D

Sažetak
Low 25-hydroxyvitamin D (25(OH)D) has been associated with inflammation, human immunodeficiency virus (HIV) disease progression, and death. We aimed to identify the prognostic value of 25(OH)D for AIDS, non-AIDS-defining events and death, and its association with immunological/inflammatory markers. Prospective 1-1 case-control study nested within the EuroSIDA cohort. Matched cases and controls for AIDS (n = 50 matched pairs), non-AIDS-defining (n = 63) events and death (n = 41), with plasma samples during follow-up were selected. Conditional logistic regression models investigated associations between 25(OH)D levels and annual 25(OH)D change and the probability of events. Mixed models investigated relationships between 25(OH)D levels and immunological/inflammatory markers. In sum, 250 patients were included. Median time between first and last sample and last sample and event was 44.6(interquartile range [IQR]: 22.7-72.3) and 3.1(IQR: 1.4-6.4) months. Odds of death decreased by 46.0%(95% confidence interval [CI], 2.0-70.0, P = .04) for a 2-fold increase in latest 25(OH)D level. There was no association between 25(OH)D and the occurrence of AIDS or non-AIDS-defining events (P > .05). In patients with current 25(OH)D <10 ng/mL, hsIL-6 concentration increased by 4.7%(95% CI, .2, 9.4, P = .04) annually after adjustment for immunological/inflammatory markers, and no change in hsCRP rate was observed (P = .76). Low Vitamin D predicts short term mortality in HIV-positive persons. Effectiveness of vitamin D supplementation on inflammation and patient outcomes should be investigated.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

Napomena
EuroSIDA in EuroCOORD.



POVEZANOST RADA

Profili:

Avatar Url Josip Begovac (autor)

Poveznice na cjeloviti tekst rada:

doi academic.oup.com doi.org

Citiraj ovu publikaciju:

Shepherd, L.; Souberbielle, J.C.; Bastard, J.P.; Fellahi, S.; Capeau, J.; Reekie, J.; Reiss, P.; Blaxhult, A.; Bickel, M.; Leen, C. et al.
Prognostic value of vitamin D level for all-cause mortality, and association with inflammatory markers, in HIV-infected persons // The Journal of infectious diseases, 210 (2014), 2; 234-243 doi:10.1093/infdis/jiu074 (međunarodna recenzija, članak, znanstveni)
Shepherd, L., Souberbielle, J., Bastard, J., Fellahi, S., Capeau, J., Reekie, J., Reiss, P., Blaxhult, A., Bickel, M. & Leen, C. (2014) Prognostic value of vitamin D level for all-cause mortality, and association with inflammatory markers, in HIV-infected persons. The Journal of infectious diseases, 210 (2), 234-243 doi:10.1093/infdis/jiu074.
@article{article, author = {Shepherd, L. and Souberbielle, J.C. and Bastard, J.P. and Fellahi, S. and Capeau, J. and Reekie, J. and Reiss, P. and Blaxhult, A. and Bickel, M. and Leen, C. and Kirk, O. and Lundgren, J.D. and Mocroft, A. and Viard, J.P. and Begovac, Josip}, year = {2014}, pages = {234-243}, DOI = {10.1093/infdis/jiu074}, keywords = {C-reactive protein, HIV, IL-6, all-cause death, inflammation, soluble CD14, vitamin D}, journal = {The Journal of infectious diseases}, doi = {10.1093/infdis/jiu074}, volume = {210}, number = {2}, issn = {0022-1899}, title = {Prognostic value of vitamin D level for all-cause mortality, and association with inflammatory markers, in HIV-infected persons}, keyword = {C-reactive protein, HIV, IL-6, all-cause death, inflammation, soluble CD14, vitamin D} }
@article{article, author = {Shepherd, L. and Souberbielle, J.C. and Bastard, J.P. and Fellahi, S. and Capeau, J. and Reekie, J. and Reiss, P. and Blaxhult, A. and Bickel, M. and Leen, C. and Kirk, O. and Lundgren, J.D. and Mocroft, A. and Viard, J.P. and Begovac, Josip}, year = {2014}, pages = {234-243}, DOI = {10.1093/infdis/jiu074}, keywords = {C-reactive protein, HIV, IL-6, all-cause death, inflammation, soluble CD14, vitamin D}, journal = {The Journal of infectious diseases}, doi = {10.1093/infdis/jiu074}, volume = {210}, number = {2}, issn = {0022-1899}, title = {Prognostic value of vitamin D level for all-cause mortality, and association with inflammatory markers, in HIV-infected persons}, keyword = {C-reactive protein, HIV, IL-6, all-cause death, inflammation, soluble CD14, vitamin D} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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