Naslov
In vitro dissolution/release methods for novel mucosal drug delivery systems

Autori
Jug, Mario ; Hafner, Anita ; Lovrić, Jasmina ; Lusina Kregar, Maja ; Pepić, Ivan ; Vanić, Željka ; Cetina- Čižmek, Biserka ; Filipović-Grčić, Jelena

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of Abstracts / Mandić, Zoran - Zagreb : International Association of Physical Chemists (IAPC), 2017, 3-3

Skup
Sixth World Conference on Physico-Chemical Methods in Drug Discovery & Third World Conference on ADMET and DMPK

Mjesto i datum
Zagreb, Hrvatska, 04.09.2017. - 07.09.2017

Vrsta sudjelovanja
Plenarno

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
in vitro release ; ocular drug delivery system ; nasal drug delivery system ; Oromucosal drug delivery system ; vaginal drug delivery system ; rectal drug delivery systems

Sažetak
In vitro dissolution/release tests are an important tool in the drug product development phase as well as in its quality control and the regulatory approval process. Mucosal drug delivery systems are aimed to provide both local and systemic drug action via mucosal surfaces of the body and exhibit significant differences in formulation design, as well as in their physicochemical and release characteristics. Therefore it is not possible to devise a single method which would be suitable for release testing of such complex dosage forms. This presentation is aimed to provide a comprehensive review of both compendial and noncompendial methods used for in vitro dissolution/release testing of novel mucosal drug delivery systems aimed for ocular, nasal, oromucosal, vaginal and rectal administration. Different apparatuses and techniques for in vitro release testing are designed and developed for mucosal delivery systems considering the specific conditions at the administration site. In order to avoid unnecessary proliferation of equipment and method design, compendial apparatuses and methods should be used as a first approach in method development when applicable. However, to assure adequate simulation of conditions in vivo, novel biorelevant in vitro dissolution/release methods should be developed enabling the prediction of formulation performance in vivo and, preferably, the establishment of an in vitro/in vivo correlation. Equipment set up, the selection of dissolution media and volume, membrane type, agitation speed, temperature, and assay analysis technique need to be carefully defined based on mucosal drug delivery system characteristics. All those parameters depend on the delivery system and physiological conditions at the site of application and may vary in a wide range, which will be discussed in details.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija

POVEZANOST RADA