Naslov
An overview of in vitro dissolution/release methods for novel mucosal drug delivery systems

Autori
Jug, Mario ; Hafner, Anita ; Lovrić, Jasmina ; Lusina Kregar, Maja ; Pepić, Ivan ; Vanić, Željka ; Cetina- Čižmek, Biserka ; Filipović-Grčić, Jelena

Izvornik
Journal of pharmaceutical and biomedical analysis (0731-7085) 147 (2018); 350-366

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
In vitro release ; Ocular drug delivery system ; Nasal drug delivery system ; Oromucosal drug delivery system ; Vaginal drug delivery system ; Rectal drug delivery systems

Sažetak
In vitro dissolution/release tests are an important tool in the drug product development phase as well as in its quality control and the regulatory approval process. Mucosal drug delivery systems are aimed to provide both local and systemic drug action via mucosal surfaces of the body and exhibit significant differences in formulation design, as well as in their physicochemical and release characteristics. Therefore it is not possible to devise a single test system which would be suitable for release testing of such complex dosage forms. This article is aimed to provide a comprehensive review of both compendial and noncompendial methods used for in vitro dissolution/release testing of novel mucosal drug delivery systems aimed for ocular, nasal, oromucosal, vaginal and rectal administration.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija

POVEZANOST RADA