Naslov
Fate of hydroxychloroquine in the aquatic environment

Autori
Babić, Sandra ; Dabić, Dario ; Ćurković, Lidija

Vrsta, podvrsta i kategorija rada
Radovi u zbornicima skupova, cjeloviti rad (in extenso), znanstveni

Izvornik
Proceedings of the 15th International Conference on Environmental Science and Technology / Lekkas, D.F. - Atena : Kalliopi Vrentzou, 2017, 1-5

ISBN
978-960-7475-53-4

Skup
15th International Conference on Environmental Science and Technology

Mjesto i datum
Rodos, Grčka, 31.08.2017. - 02.09.2017

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
pharmaceuticals ; hydroxychloquine ; hydrolysis ; photolysis

Sažetak
Hydroxychloroquine (HCQ) is a drug used to prevent or treat malaria infections and to treat certain autoimmune diseases such as lupus and rheumatoid arthritis. It is a high production volume pharmaceutical and has a potential for being persistent and bioaccumulative. In this work hydrolytic and photolytic stability of hydroxychloroquine was investigated. Hydrolytic stability was examined according to the OECD guideline 111 and preliminary results show that hydroxychloroquine is resistant to hydrolytic degradation. The photolytic degradation of HCQ was investigated under simulated solar radiation in MilliQ water and spring water. The results showed that investigated pharmaceutical degrade very slowly with half-laves of 5.5 h and 11.6 h in spring and MilliQ water, respectively. Effect of pH value on photodegradation rate was examined and results show significantly influence, faster degradation was observed at higher pH value. Obtained half-lives ranged from 23.1 h for pH 4 to 5.5 min for pH 9. Photodegradation followed first order kinetics with coefficients of determination (r2) higher than 0.99. Samples from hydrolytic and photolytic experiments were analyzed using high performance liquid chromatography.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA