Naslov
Acute exhausting exercise session affects endothelium-dependent, but not endothelium- independent vasodilation in professional rowers

Autori
Stupin, Marko ; Stupin, Ana ; Rašić, Lidija ; Ćosić, Anita ; Kolar, Luka ; Lenasi, Helena ; Drenjančević, Ines

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Acta Physiologica 221, S713, 1-290 / - , 2017, 74 (A02-5)

Skup
FEPS 2017

Mjesto i datum
Beč, Austrija, 13.09.2017. - 15.09.2017

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
acute exercise, endothelium, rowers, acetylcholine, sodium nitroprusside

Sažetak
Aim: We previously reported that a single exposure to exhausting training (AE) impaired endothelium- dependent vasodilation in skin microcirculation of professional rowers. Present study aimed to test if AE affect endothelium-independent vasodilation in skin microcirculation, or if microvascular reactivity impairment is limited to endothelial dysfunction. Methods: 20 professional rowers participated in this study. Blood pressure, heart rate, body mass index, waist to hip ratio, fasting lipid panel, plasma glucose and C reactive protein (CRP) were measured in all subjects. They all underwent AE. Blood lactate levels, arterial blood gas analysis and acid base status were measured before and after AE. Cutaneous microvascular blood flow was assessed by Laser Doppler Flowmetry in response to iontophoresis of sodium nitroprusside (SNP) (endothelium-independent vasodilator) before and after AE. Results: All rowers were normotensive, lean males, with normal lipidogram, glucose and CRP blood levels. Serum lactate significantly increased and metabolic acidosis occurred after AE. Systolic blood pressure and heart rate significantly increased during AE. The SNP-induced dilation was not significantly changed after AE and was similar to pre AE measurements (SNP% increase before AE 1017±280 vs. after AE 1089±253, P=0.132). Conclusion: This study demonstrated that AE did not provoke any change in endothelium- independent dilation in rowers. Taken together with our previous finding of impaired ACh- induced dilation in AE, present data suggest that AE affects microvascular function in professional rowers through its adverse impact on endothelial function. Support: VIF2015- MEFOS-05 and Osijek-Baranja County grant 2014- 2016.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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