Pregled bibliografske jedinice broj: 890662
Halogen bonded cocrystals of active pharmaceutical ingredients: pyrazinamide, lidocaine and pentoxifylline
Halogen bonded cocrystals of active pharmaceutical ingredients: pyrazinamide, lidocaine and pentoxifylline // Solid-State Science & Research - Book of Abstracts / Juribašić Kulcsár, Marina ; Halasz, Ivan (ur.).
Zagreb: Institut Ruđer Bošković, 2017. str. 90-90 (poster, nije recenziran, sažetak, znanstveni)
CROSBI ID: 890662 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Halogen bonded cocrystals of active pharmaceutical
ingredients: pyrazinamide, lidocaine and
pentoxifylline
Autori
Choquesillo-Lazarte, Duane ; Nemec, Vinko ; Cinčić, Dominik
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
Solid-State Science & Research - Book of Abstracts
/ Juribašić Kulcsár, Marina ; Halasz, Ivan - Zagreb : Institut Ruđer Bošković, 2017, 90-90
ISBN
978-953-7941-15-4
Skup
Solid-State Science & Research
Mjesto i datum
Zagreb, Hrvatska, 28.06.2017. - 30.06.2017
Vrsta sudjelovanja
Poster
Vrsta recenzije
Nije recenziran
Ključne riječi
active pharmaceutical ingredients, cocrystals, crystal engineering, halogen bonding, mechanochemistry
Sažetak
In this work we present the cocrystallization of three model active pharmaceutical ingredients: pyrazinamide (pza), lidocaine (ldc) and pentoxifylline (pxf). As cocrystal coformers, we selected perfluorinated halogen bond donors, 1, 4- diiodotetrafluorobenzene (tfib) and 1, 4- dibromotetrafluorobenzene (tfbb) [1]. From a crystal engineering standpoint the compounds are interesting due to the presence of various potential donor and acceptor species. The choice of structurally equivalent, ditopic linear halogen bond donors, yet of different donor strength allowed us to study the competition between hydrogen and halogen bonding in obtained solids. We have prepared six cocrystals by both mechanochemical synthesis and conventional solution-based method. The results of our work show that the dominant supramolecular bond in pza cocrystals is the X···N type halogen bond (where X = Br or I) established with the pyrazinyl nitrogen atom, in ldc cocrystals it is the X···O type halogen bond, while in pxf cocrystals it is dependent on the donor strength. In the tfib cocrystal, halogen bonds are established with both the secondary nitrogen atom and the xanthyl oxygen atom, while in the tfbb cocrystal only Br···O halogen bonds are formed. [1] G. Cavallo, P. Metrangolo, R. Milani, T. Pilati, A. Priimägi, G. Resnati, G. Terraneo, Chem. Rev. 116 (2016) 2478.
Izvorni jezik
Engleski
Znanstvena područja
Kemija
POVEZANOST RADA
Projekti:
HRZZ-IP-2014-09-7367 - Kristalno inženjerstvo višekomponentinih metaloorganksih materijala povezanih halogenskom vezom: ususret supramolekulskom ugađanju strukture i svojstava (CrystEngMOM) (Cinčić, Dominik, HRZZ - 2014-09) ( CroRIS)
Ustanove:
Prirodoslovno-matematički fakultet, Zagreb
