Naslov
ESI MS/MS study of Fe(III) and Ga(III) complexes with aromatic hydrazones derived from nicotinic acid hydrazide

Autori
Galić, Nives ; Benković, Tomislav ; Kontrec, Darko ; Budimir, Ana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
XIX Euroanalysis 2017: Poster presentation abstracts / - Stockholm, 2017, 74-74

Skup
XIX Euroanalysis 2017

Mjesto i datum
Stockholm, Švedska, 28.08.2017. - 01.09.2017

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Aromatic hydrazones ; Complexes ; Mass spectrometry

Sažetak
Aromatic hydrazones have been shown as promising iron-chelating agents [1]. Recent studies have shown that salicylidene acylhydrazide strongly binds gallium and that chelation of Ga(III) increase the stability of hydrazones against acid-induced hydrolysis 2. In this work three hydrazone derivatives, namely N’-(2-hydroxy-3- methoxyphenylmethylidene)-3-pyridine- carbohydrazide (1), N’-(2-hydroxy-4- methoxyphenylmethylidene)-3- pyridinecarbohydrazide (2) and N’-(2-hydroxy-5- methoxyphenylmethylidene)-3- pyridinecarbohydrazide (3), were prepared and their complexes with Fe(III) and Ga(III) ions in acidic methanol/water 1/1 media were analysed by ESI MS. Since aroylhydrazones can be involved in keto- enol tautomeric interconversion, they can act as neutral, monoanionic or dianionic ONO tridentate ligands [3]. Comprehensive MS/MS analyses were performed on singly and doubly charged ions of 1–3 complexes with Fe(III) and Ga(III), and fragmentation pathways were proposed. Hydrazones dominately coordinate as doubly deprotonated ONO ligands. The stability of ligands was increased upon complexation [4]. The results of MS analysis were compared with those obtained by spectrophotometric titrations.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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