Naslov
Value of intermediates in drug design – example of novel L-ascorbic acid derivatives

Autori
Stepanić, Višnja ; Meščić, Andrijana ; Harej, Ana ; Kraljević Pavelić, Sandra ; Raić-Malić, Silvana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
6th IAPC Meeting , Sixth World Conference on Physico-Chemical Methods in Drug Discovery & Third World Conference on ADMET and DMPK : Book of Abstracts / Mandić, Zoran - Zagreb : International Association of Physical Chemists (IAPC), 2017, 91-91

Skup
6th IAPC Meeting Sixth World Conference on Physico-Chemical Methods in Drug Discovery & Third World Conference on ADMET and DMPK

Mjesto i datum
Zagreb, Hrvatska, 04.09.2017. - 06.09.2017

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
ascorbic acid ; ADMET ; antiproliferative ; PCA

Sažetak
In our search of new hybrids of L-ascorbic acid and diverse pharmacophoric scaffolds as potential anticancer agents, novel conjugates of 1, 2, 3- triazole and L-ascorbic acid are synthesized using Cu(I) catalyzed click reaction (CuAAC) [1, 2]. Herein considered dibenzylated compounds are obtained as intermediates in the synthesis of target derivatives of vitamin C. The library of compounds with reasonable ADME/Tox profile is designed in a way to span physicochemical space by varying a substituent at position R1 of 1, 2, 3- triazole ring and by elimination of C5-OH group and introduction of C4=C5 double bond (Fig. 1).

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Temeljne medicinske znanosti

POVEZANOST RADA