Naslov
Influence of dexamethasone administration in spinal anesthesia for femur fracture

Autori
Šakić, Livija ; Šakić, Kata ; Tonković, Dinko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts and Highlight Papers of the 35th Annual European Society of Regional Anaesthesia & Pain Therapy (ESRA) Congress 2016 ; u: Regional anesthesia and pain medicine 41 (2016) (S) e1-e162 / - , 2014, E98-e98

Skup
Annual European Society of Regional Anaesthesia & Pain Therapy (ESRA) Congress (35 ; 2016)

Mjesto i datum
XX, XXX, Xx.-xx.xx.20014

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Deksametazon ; spinalna anestezija ; prijelom bedrene kosti
(dexamethasone ; spinal anaesthesia ; femur fracture)

Sažetak
The aim of this research is to establish the influence of intrathecal dexamethasone administration in spinal anesthesia with levobupivacaine on postoperative pain, consciousness and values of cortisol levels for patients with femur fracture. The study is planned as a prospective, interventional, randomized clinical trial.A total of 60 patients ASA2 and ASA3 status, scheduled for surgical procedures will be sorted into two groups and undergo surgery in spinal anesthesia with 12, 5mg of levobupivacaine (SA) and with or without 8mg of dexamethasone (DSA). The primary outcome measure is the occurrence of postoperative disturbance of consciousness and plasma cortisol levels. As a secondary outcome measure, we are following pain intensity, blood glucose levels and recovery. Cortisol and glucose are analyzed in five measurements. Peripheral venous blood samples are collected before anesthesia, one hour after surgery, third, fifth and on the tenth day after surgery. Postoperative delirium is defined by using Confusion Assessment Method (CAM) criteria. Visual analogue scale (VAS) is used to record pain severity among patients. We collected data for 16 patients so far. As expected, cortisol plasma levels (preoperative mean values 715 nmol/L and postoperative 210 nmol/L) were significantly lower in all patients having spinal anesthesia with levobupivacaine and dexamethasone in comparison to patients in spinal anesthesia with only local anesthetic(preoperative mean values 807 nmol/L and postoperative 713 nmol/L).According to CAM criteria postoperative cognitive disturbances were seen in 5 patients after spinal anesthesia with only local anesthetic. The addition of dexamethasone to the local anesthetic significantly prolongs the duration of sensory block and decreases opioid requirements and postoperative cognitive disturbances.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA