Naslov
Pyrrolocytosine-pyrene hybrids as new chemical receptors for the molecular recognition of nucleic acids

Autori
Ban, Željka ; Žinić, Biserka ; Piantanida, Ivo

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry : Book of abstracts / - , 2017, 118-118

Skup
EFMC-ASMC'17 ; EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry

Mjesto i datum
Beč, Austrija, 27.08.2017. - 31.08.2017

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
Pyrrolocytosine ; pyrene

Sažetak
Small fluorescent molecules targeting DNA/RNA have attracted significant scientific interest due to the medicinal, biochemical and biological implications of such molecular recognition events. According to the previous results, we designed and synthesized new type of molecular probes, containing pyrene as fluorophore, as well as DNA-intercalator unit and fluorescent pyrrolocytosine (Pyrr-C), which should by Watson-Crick base-pairing capacity recognise guanine. Three novel Pyrr-Cpyrene hybrids 3 and 4, as well as bis(pyrenyl) hybrid 5 were synthesized. The spectrophotometric properties of compounds 3-5 and their interactions with ds-DNA and ds-RNA were studied by UV/Vis, fluorescence and CD spectroscopy. Their bioactivity and cellular uptake will be tested on a panel of human tumour cell lines.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA