Naslov
Synthesis, Anticancer and Antiviral Activity of Novel 8-(4-Substituted-1H-1, 2, 3-triazol-1- yl)purine Derivatives

Autori
Saftić, Dijana ; Glavaš-Obrovac, Ljubica ; Studzińska, Mirosława ; Paradowska, Edyta ; Leśnikowski, Zbigniew J. ; Žinić, Biserka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
VII. EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry : Abstract Book / Briner, Karin ; Carreira, Erick M. - Beč, 2017, 322-322

Skup
EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry

Mjesto i datum
Beč, Austrija, 27.08.2017. - 31.08.2017

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
acyclovir ; purines ; click chemistry ; antiviral ; anticancer

Sažetak
Acyclic guanosine analogues are unique class of heterocyclic compounds of interest as agents with proved biologically activity in many cases. The mechanism of their biological activity is based usually on disruption of the metabolic process in which the natural metabolite is an essential part. Thus, phosphorylated into the corresponding 5-O- triphosphates, and incorporated in the growing DNA or RNA chain they terminate virus replication or cancer cell division. Important representative of this class of medicines is acyclovir (ACV), an efficient drug which selectively inhibits DNA replication of the herpes family viruses. Therefore, our research was directed to the synthesis of compounds structurally related to the commercially successful drug acyclovir and screening of the new ACV analogues for antiviral and cytostatic activity.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA