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Pregled bibliografske jedinice broj: 888130

Identification of clusters of rapid and slow decliners among subjects at risk for Alzheimer’s disease

Gamberger, Dragan; Lavrač, Nada; Srivatsa, Shantanu; Tanzi, Rudolph E.; Doraiswamy, Murali
Identification of clusters of rapid and slow decliners among subjects at risk for Alzheimer’s disease // Scientific Reports, 7 (2017), 6763-1 doi:10.1038/s41598-017-06624-y (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 888130 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Identification of clusters of rapid and slow decliners among subjects at risk for Alzheimer’s disease

Autori
Gamberger, Dragan ; Lavrač, Nada ; Srivatsa, Shantanu ; Tanzi, Rudolph E. ; Doraiswamy, Murali

Izvornik
Scientific Reports (2045-2322) 7 (2017); 6763-1

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Alzheimer's_disease ; Rapid_decliners, Data_clustering ; Mild_cognitive_impairment ;
(Alzheimer's_disease ; Rapid_decliners, Data_clustering ; Mild_cognitive_impairment ; ;)

Sažetak
The heterogeneity of Alzheimer’s disease contributes to the high failure rate of prior clinical trials. We analyzed 5-year longitudinal outcomes and biomarker data from 562 subjects with mild cognitive impairment (MCI) from two national studies (ADNI) using a novel multilayer clustering algorithm. The algorithm identified homogenous clusters of MCI subjects with markedly different prognostic cognitive trajectories. A cluster of 240 rapid decliners had 2-fold greater atrophy and progressed to dementia at almost 5 times the rate of a cluster of 184 slow decliners. A classifier for identifying rapid decliners in one study showed high sensitivity and specificity in the second study. Characterizing subgroups of at risk subjects, with diverse prognostic outcomes, may provide novel mechanistic insights and facilitate clinical trials of drugs to delay the onset of AD.

Izvorni jezik
Engleski

Znanstvena područja
Računarstvo



POVEZANOST RADA

Projekti:
HRZZ-IP-08-2014-9623

Ustanove:
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Dragan Gamberger (autor)

Poveznice na cjeloviti tekst rada:

doi www.nature.com

Citiraj ovu publikaciju:

Gamberger, Dragan; Lavrač, Nada; Srivatsa, Shantanu; Tanzi, Rudolph E.; Doraiswamy, Murali
Identification of clusters of rapid and slow decliners among subjects at risk for Alzheimer’s disease // Scientific Reports, 7 (2017), 6763-1 doi:10.1038/s41598-017-06624-y (međunarodna recenzija, članak, znanstveni)
Gamberger, D., Lavrač, N., Srivatsa, S., Tanzi, R. & Doraiswamy, M. (2017) Identification of clusters of rapid and slow decliners among subjects at risk for Alzheimer’s disease. Scientific Reports, 7, 6763-1 doi:10.1038/s41598-017-06624-y.
@article{article, author = {Gamberger, Dragan and Lavra\v{c}, Nada and Srivatsa, Shantanu and Tanzi, Rudolph E. and Doraiswamy, Murali}, year = {2017}, pages = {6763-1-6763-12}, DOI = {10.1038/s41598-017-06624-y}, keywords = {Alzheimer's\_disease, Rapid\_decliners, Data\_clustering, Mild\_cognitive\_impairment, }, journal = {Scientific Reports}, doi = {10.1038/s41598-017-06624-y}, volume = {7}, issn = {2045-2322}, title = {Identification of clusters of rapid and slow decliners among subjects at risk for Alzheimer’s disease}, keyword = {Alzheimer's\_disease, Rapid\_decliners, Data\_clustering, Mild\_cognitive\_impairment, } }
@article{article, author = {Gamberger, Dragan and Lavra\v{c}, Nada and Srivatsa, Shantanu and Tanzi, Rudolph E. and Doraiswamy, Murali}, year = {2017}, pages = {6763-1-6763-12}, DOI = {10.1038/s41598-017-06624-y}, keywords = {Alzheimer's\_disease, Rapid\_decliners, Data\_clustering, Mild\_cognitive\_impairment, , }, journal = {Scientific Reports}, doi = {10.1038/s41598-017-06624-y}, volume = {7}, issn = {2045-2322}, title = {Identification of clusters of rapid and slow decliners among subjects at risk for Alzheimer’s disease}, keyword = {Alzheimer's\_disease, Rapid\_decliners, Data\_clustering, Mild\_cognitive\_impairment, , } }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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