Naslov
Reakcije kvaternizacije derivata piridina pod utjecajem mikrovalnog zračenja i njihova antibakterijska aktivnost
(Microwave - assisted quaternization of various pyridine derivatives and their antibacterial activity)

Autori
Bušić, Valentina ; Gašo-Sokač, Dajana ; Pavlović, Hrvoje

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of abstracts, 25th Croatian Meeting of Chemists and Chemical Engineers (25HSKIKI) / Šantić, Ana ; Đaković, Marijana - Zagreb : Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI) ; Hrvatsko kemijsko drustvo, 2017, 128-128

Skup
XXV. hrvatski skup kemičara i kemijskih inženjera,

Mjesto i datum
Poreč, Hrvatska, 19.04.2017. - 22.04.2017

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
piridin, derivati piridina, kvaternizacija, kvaterne piridinijeve soli, mikrovalna sinteza
(pyridine, pyridine derivates, quaternization, quaternary pyridinium salts, microwave sythesis)

Sažetak
Numerous pyridinium derivatives have been investigated concerning their biological and pharmacological activities. Their importance lies in their effective antimicrobial, antiviral, antihypertensive and immunostimulating activities. Some of pyridinium aldo xime derivatives are potential antidotes against organophosphate poisoning. In this study, reactions of quaternization under microwave heating of pyridine, α - picoline, pyridine-4-aldoxyime, pyridine-2- aldoxime, nicotinamide, isonicotinamide and pyridoxal oxime with different electrophiles: 2-bromo-4'-nitroacetophenone, 2-amino-4-chloromethylthiazole hydrochloride, methyl iodide, 1, 3-diiodopropane and 1, 3-dibromopropane are reported. The synthesis yield by microwave dielectric heating is improved and reaction time shortened compared to conventional heating. Some of the synthesized compounds were tested regarding their potential antibacterial activity against two Gram-positive and two Gram-negative bacteria. Antibacterial assessment showed a relatively high efficacy of 1-[2-(4-nitrophenyl)-2-oxoethyl]pyridinium bromide against G-positive and G-negative bacteria.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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