Naslov
The possible role of the tumour necrosis factor polymorphisms and human leucocyte antigens in the development of prostate cancer

Autori
Štingl Janković, Katarina ; Hudolin, Tvrtko ; Kaštelan, Željko ; Žunec, Renata ; Grubić, Zorana

Izvornik
International journal of immunogenetics (1744-3121) 43 (2016), 3; 143-150

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
TNF ; HLA ; prostate cancer

Sažetak
The cause of prostate cancer (PC), one of the most common cancers found among ageing men, remains unclear, but genetic predisposition is believed to play a major role in its aetiology. The aim of the study was to examine HLA genes polymorphism and TNF polymorphisms in PC development. Patients diagnosed with PC (N = 113) and 150 healthy individuals were tested for HLA-A, HLA-B and HLA-DRB1 genes and for TNFa, TNFb and TNFd microsatellites. The comparison of patients and controls revealed a positive association of HLA-DRB1*12, TNFa2 and TNFb5, and a negative association of HLA-DRB1*13 and TNFb4 with PC. A division of patients into groups according to age, pre-operative PSA level, Gleason score (GS) and involvement of prostatic capsule, seminal vesicles or bladder neck and perineural invasion of PC demonstrated the following: a positive correlation of HLA-DRB1*12 and a negative correlation of HLADRB1* 13 with younger patients (<65 years), GS > 7 and the positive association of prostatic capsule, seminal vesicles, bladder neck and perineural invasion of PC ; TNFb4 allele’s negative association with older patients displaying higher PSA levels, higher GS and positive surrounding tissue involvement ; positive association of TNFb5 allele for both older and younger patients. Investigation of HLA genes and TNF microsatellites demonstrated a possible role of HLADRB1 and TNF regions in PC aetiology.

Izvorni jezik
Engleski

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