Naslov
Coronary microvascular dysfunction in diabetes mellitus

Autori
Kibel, Aleksandar ; Selthofer-Relatić, Kristina ; Drenjančević, Ines ; Bačun, Tatjana ; Bošnjak, Ivica ; Kibel, Dijana ; Gros, Mario

Izvornik
Journal of international medical research (0300-0605) 45 (2017), 6; 1901-1929

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Diabetes mellitus, coronary microvascular dysfunction, microcirculation, endothelial dysfunction, cardiomyopathy, artery, nitric oxide, arachidonic acid metabolites

Sažetak
The significance, mechanisms and consequences of coronary microvascular dysfunction associated with diabetes mellitus are topics into which we have insufficient insight at this time. It is widely recognized that endothelial dysfunction that is caused by diabetes in various vascular beds contributes to a wide range of complications and exerts unfavorable effects on microcirculatory regulation. The coronary microcirculation is precisely regulated through a number of interconnected physiological processes with the purpose of matching local blood flow to myocardial metabolic demands. Dysregulation of this network might contribute to varying degrees of pathological consequences. This review discusses the most important findings regarding coronary microvascular dysfunction in diabetes from pre- clinical and clinical perspectives.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA