Naslov
Human and Neanderthal HORs in NBPF genes chromosome 1-DNA sequence difference and similarities

Autori
Vlahović, Ines ; Glunčić, Matko ; Rosandić, Marija ; Martinjak, Ivica ; Paar, Vladimir

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
19th IUPAB and 11th EBSA Congress : Abstracts ; u: European biophysics journal 49 (2017) S1 ; 1-449 / - : Springer, 2017, S275-S275

Skup
IUPAB and 11th EBSA Congress Edinbourgh, Scotland (19 ; 2017)

Mjesto i datum
Edinburgh, Ujedinjeno Kraljevstvo, 16.07.2017. - 20.07.2017

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
HOR, human, Neanderthal genomes, DNA, GRM, chromosome 1

Sažetak
With availability to data of sequenced DNA of Neanderthal, we have opportunity to identify differences on molecular level in comparison to human DNA. Using computational Global Repeat Map – GRM1, we can identify various types of repeats that exist in DNA sequences. Our focus is on identification of higher order repeats – HORs (tandem within tandem repeats in tail to head fashion) and their comparison in different or close species. With this poster, we show differences in HORs in chromosome 1 in NBPF genes, genes responsible for human brain development and neurodegenerative diseases such as schizophrenia, autism, microcephaly and macrocephaly 2. With GRM method we identify six HORs in Neanderthal and five HORs in human based on monomer size of ~1600 bp that form ~4770 bp trimer HOR structures, while in primates those kind of structures still haven’t been identified3. Divergence of consensus HORs of all arrays between human and Neanderthal is small ~3.92%. Divergence among HORs in each array is in human less than in Neanderthal arrays – human average is ~1.68% and Neanderthal average is 6.16%. Those divergences lead us to conclusion that those HOR structures are older in Neanderthal then in humans (although, there could be small contribution to higher divergence in Neanderthal HOR structures from N bases in DNA sequence obtained). Finding HORs structures in both species could reveal differences between us and eventually give an answer why we, as human species, did survive.

Izvorni jezik
Engleski

Znanstvena područja
Fizika, Biologija, Računarstvo

POVEZANOST RADA