Naslov
Osteocalcin is associated to metabolic syndrome independent of glycaemic control in postmenopausal women with diabetes type 2

Autori
Canecki-Varžić, Silvija ; Bilić-Čurčić, Ines

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Skup
5th Croatian Scientific Conference on Endocrinology and Metabolism

Mjesto i datum
Pula, Hrvatska, 2011

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
osteocalcin ; postmenopausal women ; diabetes type 2

Sažetak
Recent studies in mice and humans demonstrated that low osteocalcin levels are associated with diabetes type 2 and insuline resistance. The objective of this study was to determine the relationship between osteocalcin and glycaemic control versus metabolic syndrome in diabetes type 2 patients. Osteocalcin, HbA1C, insulin, C-peptide, total cholesterol, HDL, LDL and tryglicerides were measured in 66 female postmenopausal patients with diabetes type 2. The patients were divided in 2 groups based on their BMI values: normal 27 and overweight 27 kg/m2. Lower levels of osteocalcin (p0, 017) and HDL (p0, 001) compared to higher levels of insulin (p0, 002), c peptide (p0, 0006) and tryglicerides (p0, 001) were found in the overweight group, while there was no significant differences in HbA1C, cholesterol and LDL levels. Osteocalcin was inversely correlated with waist circumference in all patients while with insulin, c peptide and tryglicerides inverse corellation was observed only in overweight group. HDL was positivley correlated but no correlation was seen with HbA1C. This clearly demonstrates a role of osteocalcin in the pathogenesis of metabolic syndrome independently of glucose metabolism

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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