Naslov
Phytochemical evaluation of Thymus longicaulis in comparison with Thymus vulgaris

Autori
Kindl, Marija ; Bucar, Franz ; Blažeković, Biljana ; Bival Štefan, Maja ; Vladimir-Knežević, Sanda

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Reviews on Clinical Pharmacology and Drug Therapy / Shabanov, Petr D. - Sankt Peterburg : ECO-vector, LLC, 2017, 13-13

Skup
The 21th International Congress "Phytopharm 2017" and 10th Anniversary of the TCM Research Center Graz

Mjesto i datum
Graz, Austrija, 02.07.2017. - 05.07.2017

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Thymus longicaulis ; phenolic acids ; flavonoids ; essential oil

Sažetak
Thymus longicaulis C. Presl (Lamiaceae) is a small aromatic perennial herb and a typical representative of the Illyric-Mediterranean flora. It is a traditional remedy for cold, flu, cough, nephritis and abdominal pain (1). This study was aimed to evaluate phytochemical composition of the aerial parts of T. longicaulis wild-growing in Croatia. In order to find the possibility of its use in modern phytotherapy, the results were compared with those obtained for T. vulgaris, as the officially recognised medicinal plant within the genus Thymus (2). The presence of phenolic acids and flavonoids in the methanolic extracts and terpenes from the essential oil was detected by TLC. Chromatographic profiles were established for the studied plant extracts by LC-ESI-MS/MS and RP-HPLC-DAD analysis. All detected phenolic acids belonged to derivatives of rosmarinic acid, while all identified flavonoids were flavons. Rosmarinic acid was found to be the most abundant polyphenolic constituent (48 mg/g) while among flavonoids luteolin-7-O-glucuronide was present with the highest concentration (14 mg/g). The extraction yield (V/m) of essential oil isolated by hydrodistillation was 1.7%. According to GC-MS analysis forty three compounds were identified, representing 99.7% of the total oil. The essential oil was characterised by a high percentage of the monoterpene fraction (95%) with a prevalence of oxygenated monoterpenes (61%). Thymol (43%), p-cymene (18%) and γ-terpinene (11%) were identified as the most abundant compounds. Owing to its phytochemical composition comparable to those of T. vulgaris, this medicinal plant could be considered as a new source of the pharmacopoeial herbal drugs Thymi herba and Thymi aetheroleum.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija

POVEZANOST RADA