Naslov
Application of molecular spectroscopy methods in quality control of medicines and analysis of counterfeits

Autori
Pitarević, Lovorka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Adriatic NMR, Book of Abstracts / Namjesnik, Danijel ; Pičuljan, Katarina ; Bregović, Nikola ; Novak, Predrag - Zagreb : Kemijski odsjek Prirodoslovno-matematičkog fakulteta Sveučilišta u Zagrebu, 2017, 23-23

ISBN
978-953-6076-41-3

Skup
AdriaticNMR

Mjesto i datum
Mali Ston, Hrvatska, 16.06.2017. - 18.06.2017

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Nije recenziran

Ključne riječi
molecular spectroscopy, quality control, medicine, counterfeit

Sažetak
Identification of API (active pharmaceutical ingredient) is one of the parameters in quality control in the specification of finished pharmaceutical product. It is accomplished by diverse analytical methods and techniques which mainly consist of one or both chromatographic and molecular spectrometry methods. Infrared and UV- VIS are commonly used techniques but NIR is becoming more “popular” because it can be also used in quantitative determinations and it is more in the spirit of “green chemistry”. Analysis of counterfeit drugs is not a routine job and for qualitative and quantitative determinations of a counterfeits a combination of different analytical methods and techniques is the best approach. Spectroscopic methods such as FT-IR, NIR and Raman spectroscopy are used for qualitative determinations. Sometimes, results produced by infrared spectroscopy do not yield definite answer regarding identification so NMR spectroscopy is needed and used. A quantitative determination of a counterfeit both for API and for excipients is mostly done by LC-MS.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA