Naslov
CD spectroscopy distinguishes structurally related mycotoxins = Razlikovanje strukturno sličnih mikotoksina metodom CD spektroskopije
(CD spectroscopy distinguishes structurally related mycotoxins)

Autori
Jakšić Despot, Daniela ; Šegvić Klarić, Maja ; Piantanida, Ivo

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
25. Hrvatski skup kemičara i kemijskih inženjera s međunarodnim sudjelovanjem ; 3. simpozij Vladimir Prelog : knjiga sažetaka = 25th Croatian Meeting of Chemist and Chemical Engineers with international participation. 3rd symposium “Vladimir Prelog” : Book of Abstracts / Šantić, Ana ; Đaković, Marijana - Zagreb : Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI) ; Hrvatsko kemijsko drustvo, 2017, 232-232

ISBN
978-953-552327-7

Skup
25. Hrvatski skup kemičara i kemijskih inženjera s međunarodnim sudjelovanjem ; 3. simpozij Vladimir Prelog = 25th Croatian Meeting of Chemist and Chemical Engineers with international participation. 3rd symposium “Vladimir Prelog”

Mjesto i datum
Poreč, Hrvatska, 19.04.2017. - 22.04.2017

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
CD spectroscopy ; aflatoxin B1 ; sterigmatocystin ; 5-methoxysterigmatocystin

Sažetak
Mycotoxins are secondary metabolites produced by moulds abundant in the different environments. Among these, aflatoxin B1 (AFB1) is considered one of the most toxic and is human cancerogen [1]. Structurally related furofurane derivatives (Fig. 1) sterigmatocystin (STC) and 5- methoxysterigmatocystin (5-MET-STC) are direct biosynthetic precursors in AFB1 producing Aspergilli, but also the final products of biosynthesis occurring in the different types of moulds [2]. Despite similarities in their chemical structures, their toxic properties differ and thus suggesting the differences in their physicochemical properties in water solutions. In this study we showed CD spectra of AFB1, STC and 5-MET-STC in organic and water based solvents for the first time. While the CD signal in organic solvent is of low intensity and quite similar for all of the three compounds (Fig. 2A), STC showed distinctive CD signal of unusually high intensity in water (Fig. 2B). In contrast to its structural analogues we suspect such signal of STC is due to its ability to aggregate in water as was confirmed with other methods we applied that will be presented and discussed. The significance of these results is yet to be explored, but they made the basis of a new approach in the analysis of STC in water based solutions, in addition to understanding its behavior in biological systems.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti, Javno zdravstvo i zdravstvena zaštita

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