Naslov
Pharmacogenomics: sex gender differences and application in pediatrics.

Autori
Božić, Ivana ; Omanović, Tea ; Kuna, Lucija ; Kizivat, Tomislav ; Smolić, Robert ; Včev, Aleksandar ; Smolić, Martina

Izvornik
Southeastern European medical journal (2459-9484) 1 (2017), 1; 108-120

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
pharmacogenomics ; medicine ; clinical ; pediatrics

Sažetak
Pharmacogenomics is a promising field which increasingly influences medicine and biomedical research in many areas. The aim of this article is to review recent advancements in the understanding of genetic polymorphisms and their influence on interindividual variability in drug response. Also, the main variabilities in drug response according to sex differences will be discussed. The translation of pharmacogenomics into the clinical routine as well as the challenges of achieving th e goal of personalized medicine are also discussed. The role of pharmacogenetic tests in pediatrics has not been well defined yet, but it is clear that those tests could help in resolving some issues regarding the administration of drugs to children. At th e conclusion, the foremost ethical, social and regulatory issues regarding the translation of pharmacogenomics into clinical practice and future perspectives in the field will be discussed.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA