Naslov
Humani serumski albumin – najvažniji transportni protein u krvi
(Human serum albumin – the most important transport protein in the blood)

Autori
Rimac, Hrvoje ; Bojić, Mirza

Izvornik
Farmaceutski glasnik : glasilo Hrvatskog farmaceutskog društva (0014-8202) 73 (2017), 11; 793-808

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, stručni

Ključne riječi
HSA, lijekovi
(HSA, drugs)

Sažetak
Human serum albumin (HSA) is the most abundant protein in human serum. It has numerous functions, one of which is transport of small hydrophobic molecules, such as metabolites, hormones, and nutrients, as well as drugs and toxins. This promiscuous, nonspecific affinity can lead to competition and displacement of different ligand in binding to HSA and cause increase in toxicity of displaced ligands. In this paper, the most important HSA binding sites are described and the risk of displacement interactions between different ligands is discused. While such interactions are more common between physiological (e.g. fatty acids, bilirubin, heme etc) and patophysiological ligands (e.g. indoxyl sulfate, indol-3-acetate, hypuric acid, and CMPF) and drugs, displacement interactions between drugs are also known. In certain cases these interactions can directly influence drug’s free, active concentration in blood.

Izvorni jezik
Hrvatski

Znanstvena područja
Kemija, Farmacija

POVEZANOST RADA