Naslov
Mechanistic study of mechanochemical Knoevenagel reaction
(Mechanhanistic study of mechanochemical Knoevenagel reaction)

Autori
Tireli, Martina ; Lukin, Stipe ; di Michael, Marco ; Halasz, Ivan ; Užarević, Krunoslav

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Solid-State Science & Research : book of abstracts and programme / Juribašić Kulcsar, Marina ; Halasz, Ivan - Zagreb : Institut Ruđer Bošković, 2017, 83-83

ISBN
978-953-7941-15-4

Skup
Solid-State Science & Research

Mjesto i datum
Zagreb, Hrvatska, 28.06.2017. - 30.06.2017

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
mechanistic study ; mechanochemistry ; organic reactions, Knoevenagel reaction ; in situ Raman ; Raman spectroscopy ; synchrotron XRD

Sažetak
Organic synthesis is widely used in pharmaceutical and chemical industry, but the need for cleaner and safer synthesis was the key for success of solid state reactions.[1] Mechanochemical organic reaction are carried out without the need for solvents, conventional catalysts, in shorter reaction time and with higher product yield.[2] Development of in situ methods in real time which permit reaction monitoring was extremely important for further development of mechanochemical methods and investigation of mechanistic studies. The Knoevenagel condensation is a nuchleophilic addition reaction of an active hydrogen compound to a carbonyl group and it is used for forming a new C-C bond.[3] Here we present simultaneous synchrotron powder X-ray diffraction and Raman for in situ monitoring of mechanochemical Knoevenagel reactions between aromatic aldehyde 1-4 and barbituric acid. In situ monitoring enabled us direct insight into the fundamental aspects of solid-state Knoevenagel reactions and enabled us optimization of this important class of organic reactions.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Farmacija

POVEZANOST RADA