Pregled bibliografske jedinice broj: 883545
Solvent-free Synthesis and Antibacterial Activity of 14-Aryl Substituted Dibenzoxanthene Derivatives
Solvent-free Synthesis and Antibacterial Activity of 14-Aryl Substituted Dibenzoxanthene Derivatives // Glasnik hemičara i tehnologa Bosne i Hercegovine, 46 (2016), 33-38 (podatak o recenziji nije dostupan, članak, znanstveni)
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Naslov
Solvent-free Synthesis and Antibacterial Activity of 14-Aryl Substituted Dibenzoxanthene Derivatives
Autori
Veljović, Elma ; Špirtović-Halilović, Selma ; Kahrović, Emira ; Roca, Sunčica ; Novaković, Irena ; Osmanović, Amar ; Salihović, Mirsada ; Alagić, Davor ; Hastor, Benjamin ; Ljubunčić, Dženana ; Završnik, Davorka
Izvornik
Glasnik hemičara i tehnologa Bosne i Hercegovine (0367-4444) 46
(2016);
33-38
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
dibenzoxanthenes ; solvent-free synthesis ; antibacterial activity ; docking study
Sažetak
Xanthene derivatives are important compounds because of their proven biological activities. Seven 14-aryl-14H-dibenzoxanthenederivatives were synthesized by reliable solvent-free synthesis procedure using iron (III) chloride hexahydrate as a catalyst. Three synthesized derivatives possess antibacterial activities against different bacteria. Compound 14-(2’, 5’- dimethoxyphenyl)-14H-dibenzo[a, j]xanthene(3) showed best activity against Escherichia coliand Staphylococcus aureus with MIC 0.616 mg/mL. Docking study for the most potent compound was carried out by taking amino terminal domain of enzyme I as a target for antibacterial activity against Escherichia coli and it was shown that binding energy of 3 was similar to amikacin’s (around –4.2 kcal/mol) used as a referent drug, although bound on a different sites on enzyme.
Izvorni jezik
Engleski
Znanstvena područja
Kemija
