Naslov
Interleukin-6 level in the CSF and serum of relapsing-remitting multiple sclerosis patients ; preliminary results
(. Interleukin-6 level in the CSF and serum of relapsing-remitting multiple sclerosis patients ; preliminary results)

Autori
Horvat, Gordana ; Čulo, Filip

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstact book / - Zagreb : Hrvatsko imunološko društvo, 2001, 4-4

Skup
2001 Annual Meeting of the Croatian Immunological Society

Mjesto i datum
Zagreb, Hrvatska, 15.12.2001

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
Il-6; multiple sclerosis; CSF; ELISA

Sažetak
Introduction: Inteleukin-6 (IL-6) is pleiotropic cytokine that influence antigen specific immune responses and inflammatory reactions. Multiple sclerosis is demyelinating disease of central nervous system with a variety of abnormalities involving immune system. The role of IL-6 has recently been implicated in the pathogenesis of multiple sclerosis (MS). The aim of these study was to measure IL-6 in the cerebrospinal fluid (CSF) and serum from relapsing-remitting MS (RRMS) patients during acute exacerbation of the disease. Patients and methods: We analysed CSF and serum samples from 8 RRMS patients during acute exacerbation of the disease and 9 patients with noninflammatory neurological diseases (NIND). IL-6 levels were measured using commercial enzymeimmuno test (ELISA). Student t-test was applied for statistical analysis of the data. Results: In RRMS patients average Il-6 level in CSF was 3.265 pg/ml (range 0.160-9.306) and in serum 5.255 pg/ml (range 0.457-9.985). In NIND patients average IL-6 CSF level was 8.330 pg/ml (range 0.051-35.296) and in serum 11.783 pg/ml (range 2.301-37.876). IL-6 CSF level was not measurable in the CSF of 1 MS patient and 2 NIND patients, and in the serum in 2 MS patients and in 4 NIND patients. Our preliminary results show that there is no statistically significant difference between IL-6 concentration in CSF and serum of RRMS and NIND patients. Conclusion: The preliminary results indicate that the level of IL-6 in RRMS might be lover then in NIND. However, more data are needed to confirm this.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija

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