Pregled bibliografske jedinice broj: 88249
Clinical implication of protein gradients in the lumbar cerebrospinal fluid
Clinical implication of protein gradients in the lumbar cerebrospinal fluid // Journal of Neurological Sciences
London, Ujedinjeno Kraljevstvo: Elsevier, 2001. (poster, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 88249 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Clinical implication of protein gradients in the lumbar cerebrospinal fluid
Autori
Vladić, Anton ; Horvat, Gordana ; Zadro, Ivana ; Bilić, Ervina ; Vukadin, Stipe
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
Journal of Neurological Sciences
/ - : Elsevier, 2001
Skup
XVII World Congress of Neurology
Mjesto i datum
London, Ujedinjeno Kraljevstvo, 17.06.2001. - 22.06.2001
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
concentartion gradient; proteins; CSF
Sažetak
Background: Concentration gradients for proteins between ventricular (low level), cisternal (intermediate level) and lumbar (high level) cerebrospinal fluid (CSF) have been demonstrated (1). However, although a gradient for total protein along the CSF system has been well established, the gradient for total protein along the lumbar sac has not been well studied. Objective: The objective of this study was to determine whether the gradient for total protein in the lumbar CSF exists. Patients and Methods: We studied 18 patients (age, sex) with communicating hydrocephalus (8 patients with normal pressure hydrocephalus, and 10 patients with atrophic hydrocephalus). Exactly 20 ml of lumbar CSF were collected during a lumbar puncture and the first, the fifth, the tenth, the fifteenth, and the twentieth ml of the lumbar CSF were separated into test tubes for total protein measurement using colorimetric (pyrogallol red) method. Concentrations of total protein were expressed in mg/l. The Student-t test for paired data was used for statistical evaluation. Results: Our results showed statistically significant different concentrations of total protein between the first (647, 66&plusmn ; 84, 56) and the twentieth ml (298, 69&plusmn ; 40.82) of lumbar CSF. Conclusions: These results indicate that lumbar CSF is not a homogeneous fluid and that during a lumbar puncture standardized volume of the lumbar CSF should be obtained for protein analysis.
Izvorni jezik
Engleski
Znanstvena područja
Farmacija
POVEZANOST RADA
Ustanove:
Medicinski fakultet, Zagreb
