Naslov
Polymorphisms in the PLA2G4A and PLA2G6 genes and nicotine dependence in schizophrenia patients

Autori
Nadalin, Sergej ; Rebić, Jelena ; Ružić, Klementina ; Prpić, Ante, Kapović, Miljenko ; Buretić-Tomljanović, Alena

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
The Tenth ISABS Conference on Forensic and Anthropologic Genetics and Mayo Clinic Lectures in Individualized Medicine / Primorac, Dragan ; Schanfield, Moses ; Vuk-Pavlović, Stanimir ; Kayser Manfred ; Tamas Ordog - Zagreb : Grafički zavod Hrvatske, 2017, 300-300

ISBN
978-953-57695-2-1

Skup
The fifth days of human genetics - prof. dr. sc. Ljiljana Zergollern-Čupak

Mjesto i datum
Dubrovnik, Hrvatska, 19.06.2017. - 24.06.2017

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
PLA2G4A gene, PLA2G6 gene, polymorphism, schizophrenia, smoking

Sažetak
Objective: Schizophrenia patients are often smokers which make them an interesting group to study the etiology of nicotine dependence. We investigated the relationship between the rs10798059 (BanI) and rs4375 polymorphisms in phospholipase A2 (PLA2)G4A and PLA2G6 genes and the risk of nicotine dependence in Croatian schizophrenia patients. We also tested whether interactions between these polymorphic variants and smoking status might contribute to disease onset and scores for the Positive and Negative Syndrome Scale (PANSS). Patients and methods: Genotyping was performed for 263 patients by polymerase chain reaction. Results: There were no significant differences in the distribution of PLA2G4A genotypes and alleles in patients according to smoking status and no PLA2G4A genotype-smoking interaction on disease onset or PANSS. A significant overrepresentation of PLA2G6-CC homozygous and PLA2G6-CT heterozygous genotypes was detected in male nonsmokers compared to smokers (χ2=3.03, p=0.041) ; PLA2G6-CC homozygous and PLA2G6-CT heterozygous males had about a 2.5-fold lower smoking risk than PLA2G6-TT homozygous. We also revealed a significant PLA2G6 genotype-smoking interaction that predicted the time of schizophrenia onset among males (F=4.07, p<0.05) ; an earlier onset was observed for smokers PLA2G6-TT homozygous in comparison to nonsmoking PLA2G6-TT homozygous. Conclusion: This is the first study to investigate the possible association between PLA2 genes and nicotine dependence. Significant although weak effects were detected only for the PLA2G6 polymorphism. The first showed polymorphism's effect on the risk of nicotine dependence. The second linked the PLA2G6 genotype-smoking interaction to the time of disease onset ; both effects manifested in a gender-specific fashion.

Izvorni jezik
Engleski

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