Naslov
Vitamin D in osteoporotic patients

Autori
Pavić, Marina ; Milevoj Kopcinović, Lara

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Clinical chemistry and laboratory medicine / Plebani, Mario - Berlin : Walter de Gruyter, 2017, S482-S482

Skup
22nd IFCC-EFLM European Congress of Clinical Chemistry and Laboratory Medicine - EuroMedLab

Mjesto i datum
Atena, Grčka, 11.06.2017. - 15.06.2017

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
vitamin D, osteoporosis

Sažetak
Background: Current data demonstrate that an adequate vitamin D status protects bone health by improving bone mineral density and reducing the risk of fracture. The aim of this study was to investigate and compare vitamin D concentrations in patients with osteoporosis divided according to positive history of bone fractures. Methods: Retrospectively, clinical records of 66 adult females with osteoporosis were retrieved from the hospital information system. The study group was divided according to the presence of bone fracture and the concentrations of vitamin D were extracted from our laboratory records. Vitamin D concentrations were determined by electrochemiluminiscent method (ECLIA) on the Elecsys 2010 analyzer (Roche Diagnostics GmbH, Mannheim, Germany). Results: In the whole osteoporosis group aged 71 (26-87) investigated vitamin D concentrations were 50 ± 25 nmol/L and showed no correlation with age (P = 0.503). Recommended vitamin D concentrations (≥ 75 nmol/L) were found in 13% of patients, while insufficient (50-74 nmol/L) and deficient concentrations (< 50 nmol/L) were observed in 29% and 58% of patients, respectively. Osteoporosis patients with fractures (N = 41) had lower concentrations of vitamin D compared to patients without fractures (N = 25), 43 ± 21 nmol/L vs. 61 ± 28 nmol/L, respectively (P = 0.005). Only 27% of patients with osteoporosis and 15% of patients with osteoporotic fractures were receiving vitamin D supplementation therapy. Conclusions: The majority of the osteoporosis patients investigated showed lower vitamin D concentrations than recommended. Deficient vitamin D concentrations were observed in patients with osteoporotic fractures. Adequate vitamin D supplementation is important in the regulation of calcium and phosphorus metabolism, essential for bone health.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Farmacija

POVEZANOST RADA