Naslov
Nitrous oxide added at the end of anesthesia decreases early postoperative pain

Autori
Mraović , Boris ; Šimurina, Tatjana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
11th Annual ASRA Pain Medicine Meeting Abstract Book / - , 2012, 1-188

Skup
11th Annual ASRA Pain Medicine Meeting

Mjesto i datum
Miami (FL), Sjedinjene Američke Države, 2012

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
nitrous oxide, postoperative, pain, recovery

Sažetak
NITROUS OXIDE ADDED AT THE END OF ANESTHESIA DECREASES EARLY POSTOPERATIVE PAIN Introduction: Nitrous oxide (N2O) analgesic mechanism of action is not clearly understood. Recently, an analysis of ENIGMA trial suggested that N2O may have a preventive analgesic effect. We investigated if adding N2O at the end of anesthesia to fasten recovery after isoflurane anesthesia hasinfluence on postoperative pain.Material and methods: After obtaining IRB approval and informed consents, 82 women, ASA PS I-III, scheduled for laparoscopic assisted vaginal hysterectomy were randomized into two groups according to carrier gas: GO2 - air in 30% oxygen (n=42) and GN2O - the same mixture until last 30 minutes ofthe surgery when 70% N2O and 30% oxygen was used (n=40). Anesthesia was maintained with isoflurane ~ 1MAC. Pain VAS score and total amount of postoperative opioids were recorded at 2h and 24 hours postoperatively. Diclofenac was given immediately after surgery. For severe pain (VAS >40mm) meperidine was given. Data were analyzed using Chi-Square and Mann-Whitney test.Results: There were no significant differences between two groups for age, BMI, duration of anesthesia and surgery, and intraoperative fentanyl use. G N2O patients received on average N2O for 27.1±10.1 minutes, woke up 3.8 minutes faster (p=0.01), had less pain at 2 hours (VAS 38.1±14.6 vs 47.4±15.2 mm, p=0.008) and received less meperidine (82.5 vs 100%, p=0.005). There was not difference in pain at 24 hours between groups (VAS 13.2±12.4 vs 13.0±13.0 mm, p=0.86).Discussion: Adding N2O at the end of anesthesia hastened recovery time, decreased pain at 2 hours postoperatively and number of patients who needed meperidine postoperatively.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA