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Pregled bibliografske jedinice broj: 881483

Functional Roles of E6 and E7 Oncoproteins in HPV-Induced Malignancies at Diverse Anatomical Sites


Tomaić, Vjekoslav
Functional Roles of E6 and E7 Oncoproteins in HPV-Induced Malignancies at Diverse Anatomical Sites // Cancers, 8 (2016), 10; 95, 22 doi:10.3390/cancers8100095 (međunarodna recenzija, pregledni rad, znanstveni)


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Naslov
Functional Roles of E6 and E7 Oncoproteins in HPV-Induced Malignancies at Diverse Anatomical Sites

Autori
Tomaić, Vjekoslav

Izvornik
Cancers (2072-6694) 8 (2016), 10; 95, 22

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
HPV ; cancer ; E6 and E7 oncoproteins

Sažetak
Approximately 200 human papillomaviruses (HPVs) infect human epithelial cells, of which the alpha and beta types have been the most extensively studied. Alpha HPV types mainly infect mucosal epithelia and a small group of these causes over 600, 000 cancers per year worldwide at various anatomical sites, especially anogenital and head-and-neck cancers. Of these the most important is cervical cancer, which is the leading cause of cancer-related death in women in many parts of the world. Beta HPV types infect cutaneous epithelia and may contribute towards the initiation of non- melanoma skin cancers. HPVs encode two oncoproteins, E6 and E7, which are directly responsible for the development of HPV-induced carcinogenesis. They do this cooperatively by targeting diverse cellular pathways involved in the regulation of cell cycle control, of apoptosis and of cell polarity control networks. In this review, the biological consequences of papillomavirus targeting of various cellular substrates at diverse anatomical sites in the development of HPV-induced malignancies are highlighted.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti



POVEZANOST RADA


Ustanove:
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Vjekoslav Tomaić (autor)

Poveznice na cjeloviti tekst rada:

doi fulir.irb.hr www.mdpi.com

Citiraj ovu publikaciju:

Tomaić, Vjekoslav
Functional Roles of E6 and E7 Oncoproteins in HPV-Induced Malignancies at Diverse Anatomical Sites // Cancers, 8 (2016), 10; 95, 22 doi:10.3390/cancers8100095 (međunarodna recenzija, pregledni rad, znanstveni)
Tomaić, V. (2016) Functional Roles of E6 and E7 Oncoproteins in HPV-Induced Malignancies at Diverse Anatomical Sites. Cancers, 8 (10), 95, 22 doi:10.3390/cancers8100095.
@article{article, author = {Tomai\'{c}, Vjekoslav}, year = {2016}, pages = {22}, DOI = {10.3390/cancers8100095}, chapter = {95}, keywords = {HPV, cancer, E6 and E7 oncoproteins}, journal = {Cancers}, doi = {10.3390/cancers8100095}, volume = {8}, number = {10}, issn = {2072-6694}, title = {Functional Roles of E6 and E7 Oncoproteins in HPV-Induced Malignancies at Diverse Anatomical Sites}, keyword = {HPV, cancer, E6 and E7 oncoproteins}, chapternumber = {95} }
@article{article, author = {Tomai\'{c}, Vjekoslav}, year = {2016}, pages = {22}, DOI = {10.3390/cancers8100095}, chapter = {95}, keywords = {HPV, cancer, E6 and E7 oncoproteins}, journal = {Cancers}, doi = {10.3390/cancers8100095}, volume = {8}, number = {10}, issn = {2072-6694}, title = {Functional Roles of E6 and E7 Oncoproteins in HPV-Induced Malignancies at Diverse Anatomical Sites}, keyword = {HPV, cancer, E6 and E7 oncoproteins}, chapternumber = {95} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


Citati:





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