Naslov
Protein tyrosine phosphorylation in Streptomycetes

Autori
Waters, Barbara ; Vujaklija, Dušica ; Gold, Michael R. ; Davies, Julian

Izvornik
FEMS microbiology letters (0378-1097) 120 (1994), 1/2; 187-190

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Streptomyces spp. ; Tyrosine phosphorylation ; Secondary metabolism ; Regulation of metabolism

Sažetak
Using phosphotyrosine-specific antibodies, we demonstrate that in several Streptomyces spp. a variety of proteins are phosphorylated on tyrosine residues. Tyrosine phosphorylation was found in a number of Streptomyces species including Streptomyces lividans, Streptomyces hygroscopicus and Streptomyces lavendulae. Each species exhibited a unique pattern of protein tyrosine phosphorylation. Moreover, the patterns of tyrosine phosphorylation varied during the growth phase and were also influenced by culture conditions. We suggest that metabolic shifts during the complex growth cycle of these filamentous bacteria, and possibly secondary metabolic pathways, may be controlled by the action of protein tyrosine kinases and phosphatases, as has been demonstrated in signal transduction pathways in eukaryotic organisms.

Izvorni jezik
Engleski

Znanstvena područja
Biologija

POVEZANOST RADA