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Pregled bibliografske jedinice broj: 881167

Lipid peroxidation in the pathogenesis of neuroborreliosis

Moniuszko-Malinowska, Anna; Łuczaj, Wojciech; Jarocka-Karpowicz, Iwona; Pancewicz, Sławomir; Zajkowska, Joanna; Andrišić, Luka; Žarković, Neven; Skrzydlewska Elżbieta
Lipid peroxidation in the pathogenesis of neuroborreliosis // Free radical biology & medicine, 96 (2016), 255-263 doi:10.1016/j.freeradbiomed.2016.04.032 (međunarodna recenzija, članak, znanstveni)

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Naslov
Lipid peroxidation in the pathogenesis of neuroborreliosis

Autori
Moniuszko-Malinowska, Anna ; Łuczaj, Wojciech ; Jarocka-Karpowicz, Iwona ; Pancewicz, Sławomir ; Zajkowska, Joanna ; Andrišić, Luka ; Žarković, Neven ; Skrzydlewska Elżbieta

Izvornik
Free radical biology & medicine (0891-5849) 96 (2016); 255-263

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
4-Hydroxy-2-nonenal ; CSF ; F(2)-isoprostaneas ; Fatty acids ; Lipid peroxidation ; Neuroborreliosis ; Neuroprostanes ; Phospholipases ; Plasma ; Reactive aldehydes ; Urine

Sažetak
This study analyzed the onset of lipid peroxidation (LPO) in neuroborreliosis and the effects of ceftriaxone therapy on LPO. Twenty- two patients with early neuroborreliosis and 22 healthy subjects were studied. LPO in the cerebrospinal fluid (CSF), as well as the plasma and urine was estimated by the levels of reactive aldehydes: 4-hydroxynonenal (4-HNE), 4-hydroxyhexenal, malondialdehyde, and 4- oxononenal, F2-isoprostanes and A4/J4- neuroprostanes (NPs). The plasma level of 4- HNE-protein adducts arachidonic acid (AA), docosahexaenoic acid (DHA) and vitamin E was determined. Additionally, enzymatic activities of phospholipase A2 (PLA2), platelet-activating factor acetylhydrolase (PAF-AH) and glutathione peroxidase (GSH-Px) were determined. A decrease of AA, DHA levels and GSH-Px activity in plasma was associated with a significant increase of aldehydes in the CSF, plasma and urine. Similarly, the increase of F2-isoprostanes and NPs in the CSF and plasma was associated with the decreased activity of PLA2 and PAF-AH. Ceftriaxone therapy cured patients and reduced the levels of F2-isoprostanes, NPs and reactive aldehydes. However, the activities of PLA2 and PAF-AH increased. Pathophysiological association of neuroborreliosis with systemic LPO was revealed. Effective antibiotic therapy attenuated LPO. Biomarkers of LPO could be useful to monitor the onset of neuroborreliosis and show the effectiveness of pharmacotherapy.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA

Ustanove:
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Neven Žarković (autor)

Avatar Url Luka Andrišić (autor)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com doi.org

Citiraj ovu publikaciju:

Moniuszko-Malinowska, Anna; Łuczaj, Wojciech; Jarocka-Karpowicz, Iwona; Pancewicz, Sławomir; Zajkowska, Joanna; Andrišić, Luka; Žarković, Neven; Skrzydlewska Elżbieta
Lipid peroxidation in the pathogenesis of neuroborreliosis // Free radical biology & medicine, 96 (2016), 255-263 doi:10.1016/j.freeradbiomed.2016.04.032 (međunarodna recenzija, članak, znanstveni)
Moniuszko-Malinowska, A., Łuczaj, W., Jarocka-Karpowicz, I., Pancewicz, S., Zajkowska, J., Andrišić, L., Žarković, N. & Skrzydlewska Elżbieta (2016) Lipid peroxidation in the pathogenesis of neuroborreliosis. Free radical biology & medicine, 96, 255-263 doi:10.1016/j.freeradbiomed.2016.04.032.
@article{article, author = {Moniuszko-Malinowska, Anna and \Luczaj, Wojciech and Jarocka-Karpowicz, Iwona and Pancewicz, S\lawomir and Zajkowska, Joanna and Andri\v{s}i\'{c}, Luka and \v{Z}arkovi\'{c}, Neven}, year = {2016}, pages = {255-263}, DOI = {10.1016/j.freeradbiomed.2016.04.032}, keywords = {4-Hydroxy-2-nonenal, CSF, F(2)-isoprostaneas, Fatty acids, Lipid peroxidation, Neuroborreliosis, Neuroprostanes, Phospholipases, Plasma, Reactive aldehydes, Urine}, journal = {Free radical biology and medicine}, doi = {10.1016/j.freeradbiomed.2016.04.032}, volume = {96}, issn = {0891-5849}, title = {Lipid peroxidation in the pathogenesis of neuroborreliosis}, keyword = {4-Hydroxy-2-nonenal, CSF, F(2)-isoprostaneas, Fatty acids, Lipid peroxidation, Neuroborreliosis, Neuroprostanes, Phospholipases, Plasma, Reactive aldehydes, Urine} }
@article{article, author = {Moniuszko-Malinowska, Anna and \Luczaj, Wojciech and Jarocka-Karpowicz, Iwona and Pancewicz, S\lawomir and Zajkowska, Joanna and Andri\v{s}i\'{c}, Luka and \v{Z}arkovi\'{c}, Neven}, year = {2016}, pages = {255-263}, DOI = {10.1016/j.freeradbiomed.2016.04.032}, keywords = {4-Hydroxy-2-nonenal, CSF, F(2)-isoprostaneas, Fatty acids, Lipid peroxidation, Neuroborreliosis, Neuroprostanes, Phospholipases, Plasma, Reactive aldehydes, Urine}, journal = {Free radical biology and medicine}, doi = {10.1016/j.freeradbiomed.2016.04.032}, volume = {96}, issn = {0891-5849}, title = {Lipid peroxidation in the pathogenesis of neuroborreliosis}, keyword = {4-Hydroxy-2-nonenal, CSF, F(2)-isoprostaneas, Fatty acids, Lipid peroxidation, Neuroborreliosis, Neuroprostanes, Phospholipases, Plasma, Reactive aldehydes, Urine} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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