Pregled bibliografske jedinice broj: 880171
Molecular genetics aspects of apoptosis
Molecular genetics aspects of apoptosis // 1. Hrvatski congress humane genetike s međunarodnim sudjelovanjem = 1st Croatian Congress on Human Genetics, with international participation, Zagreb, Croatia, September 22-25, 1994. / Ivo Barić, Ingeborg Barišić, Vlasta Hitrec, Biserka Nagy, Krešimir Pavelić, Ljiljana Zergollern (ur.).
Zagreb: Hrvatski liječnički zbor, 1994. str. 21-21 (pozvano predavanje, domaća recenzija, sažetak, znanstveni)
CROSBI ID: 880171 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Molecular genetics aspects of apoptosis
Autori
Durajlija, Sonja
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
1. Hrvatski congress humane genetike s međunarodnim sudjelovanjem = 1st Croatian Congress on Human Genetics, with international participation, Zagreb, Croatia, September 22-25, 1994.
/ Ivo Barić, Ingeborg Barišić, Vlasta Hitrec, Biserka Nagy, Krešimir Pavelić, Ljiljana Zergollern - Zagreb : Hrvatski liječnički zbor, 1994, 21-21
Skup
1st Croatian Congress on Human Genetics, with international participation
Mjesto i datum
Zagreb, Hrvatska, 22.09.1994. - 25.09.1994
Vrsta sudjelovanja
Pozvano predavanje
Vrsta recenzije
Domaća recenzija
Ključne riječi
apoptosis, cell death genes, cell death-associated genes, p53, bcl-2
Sažetak
Cells that dye by physiological mechanisms often undergo characteristic changes termed apoptosis. Unlike necrosis which appears to be a passive death, the process of apoptosis is usually considered an active death that requires participation of cellular processes. Given the power of molecular biological and genetic techniques, it is possible to identify genes whose expression changes with a cell's decision to commit suicide, although some examples of apoptosis, that occur in the absence of new gene expression were found. Two classes of genes involved in the process of apoptosis can be distinguished, cell death genes and cell death-associated genes. The identification of cell death genes that are directly involved in cell death regulation, has relied on genetic manipulations that disrupt gene expression. In most cases, blocking the expression of such essential genes saves the life of otherwise condemned cell. For example, tumor suppressor gene p53 and the photo-oncogene c-myc, null mutations in mice, blocking some forms of T-cell death. In contrast, bcl-2 gene offer protection from naturally occurring cell death.Death-associated genes are those whose expression is dramatically up-regulated in dying cells but that are not in themselves lethal.Therefore, they presumably act to facilitate the demise of a cell.
Izvorni jezik
Engleski
Znanstvena područja
Biologija
