Naslov
Polymorphism of HLA-A, -B, -DRB1 allele groups among kidney transplant list patients in Croatia

Autori
Salamunović, Sanja ; Burek Kamenaric, Marija ; Maskalan, Marija ; Svilicic, Danijela ; Clekovic, Danijela ; Grubic, Zorana ; Zunec, Renata

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
31st European Immunogenetics and Histocompatibility Conference (EFI) HLA Immune response Genetics and 25th Annual Meeting of the German Society for Immunogenetics (DGI) : Abstracts / Marsh, Steven G.E. - : John Wiley & Sons, 2017, 399-399

Skup
European Immunogenetics and Histocompatibility Conference (31 ; 2017) ; Annual Meeting of the German Society for Immunogenetics (25 ; 2017)

Mjesto i datum
Mannheim, Njemačka, 30.05.2017. - 02.06.2017

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
HLA, polimorfizam, transplantacija bubrega
(HLA, polymorphism, kidney transplantation)

Sažetak
This research aims to study HLA-A, -B, and DRB1 allele group frequencies of 1075 patients listed for renal transplantation covering the period 2010-2016. The underlying disease leading to their listing was not taken into consideration for the analysis. The patients coming from 35 different dialysis centers throughout the Croatia were grouped as originating from four different geographical regions of Croatia (East-EC, N=241 ; West-WC, N=142 ; Central-CC, N=93 ; and South-SC, N=259) while the patients coming from Zagreb area (N=348) were analysed separately due to the unknown geographical origin of patients. All patients were typed by PCR-SSP method as well as the control group which consisted of 1004 cadaveric donors from the same regions of Croatia. Seventeen HLA-A, 27 HLA-B, and 13 HLA-DRB1 allele groups were identified. The most frequent HLA genes in total group of patients were: HLA-A*02 (30.7%), -A*01 (13.5%), -A*03 (12.2%) ; HLA-B*35 (13.3%), -B*51 (11.6%), -B*18 (9.3) ; HLA-DRB1*11 (18.7%), -DRB1*13 (11.9%), and -DRB1*01 (11.8%). Among all patients the most present haplotypes were: HLA-A*01-B*08-DRB1*03 (4.3%), -A*02-B*18-DRB1*11 (2.5%) and -A*02-B*51-DRB1*11 (2.1%). Statistically significant differences were not observed in the HLA polymorphisms when comparing patients with controls except for the DRB1*16 in the SC region (7.5% vs. 12.2% ; P=0.003). It was observed that some of the most frequent HLA genes show statistically significant difference in frequencies between regions. For example, A*01 was significantly lower in the CC region (8.6%) compared to the WC region (15.2% ; P=0.039) and the SC region (14.7% ; P=0.037). At HLA-B locus, B*51 was detected with the lowest frequency (8.3%) in the WC in comparison to all other regions but significant P value reached only when compared to the SC (14.7% ; P=0.0124). Among DRB1 genes, DRB1*01 gene in WC (15.2%) had the highest frequency among all regions but significant difference was found compared to SC (10.0%) ; P=0.036). In conclusion, the HLA-A, -B, and -DRB1 frequencies among patients correspond to those observed among cadaveric donors. The observed differences in frequencies between analysed Croatian regions may reflect historical migrations and admixture of neighbouring populations.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Kliničke medicinske znanosti

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