Naslov
Mikrokapsuliranje dronedaron hidroklorida
(Microencapsulation of dronedarone hydrochloride)

Autori
Gretić, Matija ; Matijašić, Gordana ; Bedoić, Robert ; Horvat, Tomislav ; Talajić, Marija ; Vinčić, Josip

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
25. HRVATSKI SKUP KEMIČARA I KEMIJSKIH INŽENJERA s međunarodnim sudjelovanjem 3. simpozij „VLADIMIR PRELOG“ / Đaković, Marijana ; Miljanić, Snežana ; Šantić, Ana ; Vianello, Robert - Zagreb : Hrvatsko kemijsko društvo, 2017, 173-173

ISBN
978-953-55232-7-7

Skup
25. HRVATSKI SKUP KEMIČARA I KEMIJSKIH INŽENJERA s međunarodnim sudjelovanjem 3. simpozij „VLADIMIR PRELOG“

Mjesto i datum
Poreč, Hrvatska, 19.04.2017. - 22.04.2017

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Dronedaron hidroklorid ; Mikrokapsuliranje ; Sušenje raspršivanjem ; Kontrolirano otpuštanje
(Dronedarone hydrochloride ; Microencapsulation ; Spray drying ; Controled release)

Sažetak
Dronedarone hydrochloride is an anti-arrhythmic drug for the regulation of cardiac arrhythmia. Dronedarone is a benzofuran containing heterocyclic compound and is a structural analog of amiodarone, but with slight structural modifications where the iodine group is replaced by a methane-sulfonyl group. The intention behind the replacement of iodine group is to reduce the risk of non-target organ adverse effects caused by amiodarone therapy. Microencapsulation is a process by which tiny droplets of liquid or solid material are coated with a continuous film of polymeric or lipid material. The size, structure and form of microcapsules depend on preparation techniques, materials used and the process conditions in which they were produced. One way of obtaining the microcapsules is spray drying. Due to its simplicity, flexibility and speed of production, spray-drying has found a wide application in the pharmaceutical industry. The aim of this study was to produce microcapsules of dronedarone hydrochloride with extended- release profile by spray drying. In this study three different encapsulation materials were used ; gum arabic, gelatin and cellulose acetate phthalate. Experiments were conducted in a laboratory spray-dryer. The influence of different process conditions on the quality of the obtained microcapsules (drying air temperature, flow rate of atomizing air) was tested. The effectiveness of microencapsulation process was tested spectrophotometrically by determining the content of dronedarone hydrochloride in microcapsules. The morphology of the microcapsules was tested using scanning electron microscope. Dronedarone hydrochloride release rates were obtained and described with appropriate kinetic models. The results indicate that diversity of coating materials and process conditions enables control of dronedarone hydrochloride release in microencapsulation process.

Izvorni jezik
Engleski

Znanstvena područja
Kemijsko inženjerstvo

POVEZANOST RADA