Pregled bibliografske jedinice broj: 87935
The longitudinal follow up the dynamics of tumor marker CYFRA21-1 establish a fact of local relapse in primary NSCLC (36 month follow up study on 500 patients)
The longitudinal follow up the dynamics of tumor marker CYFRA21-1 establish a fact of local relapse in primary NSCLC (36 month follow up study on 500 patients) // The second European-American intensive course in clinical and forensic genetics.
Dubrovnik, 2001. (poster, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 87935 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
The longitudinal follow up the dynamics of tumor marker CYFRA21-1 establish a fact of local relapse in primary NSCLC (36 month follow up study on 500 patients)
Autori
Pavićević, Radomir ; Bubanović, Gordana ; Krajina, Ana ; Miličić, Jasna
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
The second European-American intensive course in clinical and forensic genetics.
/ - Dubrovnik, 2001
Skup
The second European-American intensive course in clinical and forensic genetics
Mjesto i datum
Dubrovnik, Hrvatska, 03.09.2001. - 14.09.2001
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
CYFRA-21-1 tumor marker; longitudinalno praćenje; rak pluća; NSCLC
(CYFRA-21-1 tumor marker; longitudinal follow up; lung cancer; NSCLC)
Sažetak
The clinical application of cytokeratin marker CYFRA 21-1 was standardized on 3000 patients. In all patients the start value of CYFRA 21-1 was determined before therapy (electrochemiluminescence method, Roche Diagnostics). Tumor marker CYFRA 21-1 was assessed longitudinally 1-36 months after the therapy, or before the next therapy. One to three months after the surgical treatment in 97% of the patients the marker values decreased to the healthy population level, depending on the therapy and TNM stage (p<0.0001). The decrease appeared earlier in SQC then in AD and LCLC (Large Cell Lung Carcinoma) patients. Comparing clinical follow up data and CYFRA 21-1 marker as a prognostic factors for local relapse, it was found that tumor marker predicted the local relapse 1 to 12 months earlier in 235 out of 500 patients. Among those the majority had the start value above cut off level, which pointed to the earlier onset of local relapse and shorter survival period. The CYFRA 21-1 value depends on the tumor type, the location of local relapse and the measurement interval. The assessment of chemotherapy efficiency using CYFRA 21-1 marker will be shown in 141 patients. The elevated cytokeratin marker CYFRA 21-1 value is a biological signal of earlier events in lung tumor, which is why it becomes unavoidable diagnostic and prognostic marker within clinical procedure.
Izvorni jezik
Engleski
Znanstvena područja
Etnologija i antropologija
