Naslov
Prominent role of physiology in human health and environmental risk assessment: Lessons learned from the FP7 project SOLUTIONS

Autori
Kaišarević, Sonja ; Tenji, Dina ; Šipoš, Šandor, Mičić, Branka ; Deutschmann, Björn ; Seiler, Thomas-Benjamin ; Velki, Mirna ; Hollert, Henner ; Brack, Wener ; Teodorović, Ivana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
JOINT MEETING OF NATIONAL PHYSIOLOGICAL SOCIETIES - NEW PERSPECTIVES IN PHYSIOLOGICAL RESEARCH – YOUNG INVESTIGATOR FORUM - Abstract Book / - , 2017

Skup
JOINT MEETING OF NATIONAL PHYSIOLOGICAL SOCIETIES - NEW PERSPECTIVES IN PHYSIOLOGICAL RESEARCH – YOUNG INVESTIGATOR FORUM

Mjesto i datum
Subotica, Srbija, 25.05.2017. - 27.05.2017

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
SOLUTIONS ; physiology ; risk assessment ; biomarkers

Sažetak
The EU funded collaborative FP7 project SOLUTIONS searches for new and improved tools, models, and methods to produce consistent solutions for the large number of present and future emerging chemicals posing a risk to European water bodies with respect to ecosystems and human health. In the project framework, a special focus is put on the development, validation and documentation of a diagnostic toolbox to identify and quantify in situ impacts of mixtures of pollutants integrating over single organism, population and community levels. For this purpose, a battery of in situ biomarker and bioassay analyses in tissues of caged and free-living fish specimens from the River Danube were conducted in a weight- of-evidence approach. Gene expression analyses of selected endocrine disruption and stress representative genes, and antioxidant and biotransformation enzymes activity were investigated, to estimate the physiological status of the organisms exposed to chemical stress at pollution hot spots. Obtained results were evaluated against the chemical composition of the water, and the available results of in vitro bioassays. The study demonstrated a prominent role of physiological responses of fish as a part of a complex battery to (a) contribute to a better understanding of cause-effect relationships of exposure to key pollutants, and (b) provide useful data for prioritization of contaminants and contaminant mixtures in the aquatic environment. The ultimate goal is to support decisions in environmental and water policies regarding chemical regulation and abatement measures, and minimize ecological and human health risks.

Izvorni jezik
Engleski

Znanstvena područja
Biologija

POVEZANOST RADA