Naslov
Inflammation and obesity: possible link to the pathogenesis of retinopathy in type 2 but not in type 1 diabetes

Autori
Tomić, Martina ; Vrabec, Romano ; Ljubić, Spomenka ; Blaslov, Kristina ; Smirčić-Duvnjak, Lea

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
European Journal of Ophthalmology / Brancato, Rosario ; Bandello, Francesco M. - Milano : Wichtig Publishing, 2017, E123-e123

Skup
27th Meeting of EASD Eye Complication Study Group

Mjesto i datum
Budimpešta, Mađarska, 25.05.2017. - 27.05.2017

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
retinopathy in type 1 and type 2 diabetes, risk factors

Sažetak
Purpose. To evaluate risk factors for the development of diabetic retinopathy (DR) in type 1 and type 2 diabetes and determine differences in risk factors in these two types of diabetes. Methods. 84 patients with type 1 and 107 patients with type 2 diabetes were included in this cross- sectional study. Basic and anthropometric parameters assessed were sex, age, diabetes duration, body mass index (BMI), waist circumference (WC) and waist-to-hip ratio (WHR). C-reactive protein (CRP), fibrinogen (FIB), glycated hemoglobin (HbA1c), fasting and postprandial blood glucose (fBG, ppBG), total cholesterol, HDL and LDL cholesterol and triglycerides (TG) were determined using routine laboratory methods. HbA1cmedian was obtained by statistical analysis of data from the National Diabetes Registry. Albumin excretion rate (AER) was measured from a 24-hr urine sample. Ophthalmologic examination included indirect slit lamp fundoscopy and color fundus photography of two fields of both eyes according to the EURODIAB retinal photography methodology. Results. Patients were divided into three groups: group 1 (no retinopathy), group 2 (mild/moderate NPDR) and group 3 (severe NPDR/PDR). In both types of diabetes group 3 had longer diabetes duration than group 1 (type 1 p=0.002 ; type 2 p<0.001). Group 3 in type 1 had higher HbA1cmedian (p<0.001) and AER (p=0.002), while in type 2 had higher BMI, WC, WHR, SBP, CRP, FIB, ppBG and TG than group 1. DR was positively associated with diabetes duration (p<0.001), HbA1cmedian (p<0.001) and AER (0.008) in type 1, and diabetes duration (p<0.001), HbA1cmedian (p=0.018), AER (0.001), CRP (p=0.048) and TG (p=0.041) in type 2 diabetes. Logistic regression analyses showed that diabetes duration (OR=1.22, CI 1.04-1.45, p=0.011) and prolonged poor glycemic control (HbA1cmedian) (OR=1.73, CI 1.25-2.34, p=0.022) were the main predictors of DR in type 1 diabetes. Diabetes duration (OR=1.25, CI 1.12-1.39, p<0.001), fBG (OR=1.45, CI 1.04-2.00, p=0.024) and TG (OR=2.08, CI 1.09-3.98, p=0.025) were the main predictors of DR in type 2 diabetes. Conclusion. Diabetes duration, poor glycemic control and nephropathy are the main risk factors for DR in both types of diabetes. Inflammation and obesity are associated with the development of DR in type 2 but not in type 1 diabetes.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA