Naslov
Serum bilirubin levels are negatively associated with diabetic retinopathy in patients with type 1 diabetes and normal renal function

Autori
Bulum, Tomislav ; Tomić, Martina ; Duvnjak, Lea

Izvornik
International Ophthalmology (0165-5701) 38 (2018); 1095-1101

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
bilirubin ; microvascular complications ; retinopathy ; type 1 diabetes

Sažetak
Previous studies suggested that total serum bilirubin levels are negatively associated with diabetic retinopathy (DR) and nephropathy in patients with diabetes mellitus. The objective of this study was to explore the relationship between serum total bilirubin levels and prevalence of DR in patients with type 1 diabetes (T1DM) and normal renal function. Study included 163 T1DM with normal renal function (urinary albumin excretion rate < 30 mg/24h, estimated glomerular filtration rate (eGFR) >60 mlmin-11.73m-2). Photodocumented retinopathy status was made according to the EURODIAB protocol. Patients with DR were older (49 vs 42 years, p=0.001), had higher systolic blood pressure (130 vs 120 mmHg, p=0.001), triglycerides (0.89 vs 0.77 mmol/L, p=0.01), and lower serum total bilirubin (12 vs 15 U/L, p=0.02) and eGFR (100 vs 106 mlmin-11.73m-2, p=0.03). In multivariate logistic regression analysis, only total serum bilirubin was significantly associated with risk of DR in our subjects (OR 0.88, CI 0.81- 0.96, p=0.006). These data suggest that serum total bilirubin levels are independently negatively associated with DR in T1DM with normal renal function. Prospective studies are needed to confirm whether lower serum total bilirubin has predictive value for the development of DR in T1DM with normal renal function.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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